Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China
Background: Short-term exposure to air pollution is strongly associated to cardiovascular disease (CVD) mortality; however, detailed studies in rapidly urbanizing areas remain limited. This study aimed to examine short-term associations between ambient air pollutants and CVD mortality using individu...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325009777 |
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| author | Tao Zhang Ran Yan Xu Zhang Jianping Ni Lanlan Fang Hui Zhao Yubo Ma Siyuan Liu Faming Pan |
| author_facet | Tao Zhang Ran Yan Xu Zhang Jianping Ni Lanlan Fang Hui Zhao Yubo Ma Siyuan Liu Faming Pan |
| author_sort | Tao Zhang |
| collection | DOAJ |
| description | Background: Short-term exposure to air pollution is strongly associated to cardiovascular disease (CVD) mortality; however, detailed studies in rapidly urbanizing areas remain limited. This study aimed to examine short-term associations between ambient air pollutants and CVD mortality using individual-level data in Hefei City. Methods: We conducted a case-crossover analysis involving 75,230 CVD deaths from 2017 to 2020 in Hefei, China. Individual exposure to fine particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and ozone (O3) was assessed using high-resolution satellite data (1 km resolution). The peak-effect lag days for individual pollutants within a 0–3 day exposure window were identified through conditional logistic regression analysis. Results: Each 10 µg/m3 increase in SO2 (lag 0–2) was associated with a 10.93 % (95 % CI: 6.65 %, 15.39 %) increase in CVD mortality, the strongest effect observed. PM2.5 (lag 0) and NO2 (lag 0–1) were associated with increases of 1.25 % (95 % CI: 0.82 %, 1.68 %) and 2.14 % (95 % CI: 1.38 %, 2.89 %), respectively. For CO (lag 0), each 0.1 mg/m3 increase was linked to a 1.22 % (95 % CI: 0.80 %, 1.64 %) increase in mortality. Other pollutants, including PM10 and O3, also showed weaker but statistically significant associations. Subgroup analyses revealed greater susceptibility among females and during the warm seasons compared to males and cold seasons. Conclusions: Short-term exposure to ambient air pollutants significantly increases CVD mortality risk in Hefei, particularly among females and during warm seasons. These findings underscore the need for targeted public health interventions to mitigate pollution-related cardiovascular risks. |
| format | Article |
| id | doaj-art-8c2a176013004fba8a9bade13affad09 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-8c2a176013004fba8a9bade13affad092025-08-20T03:36:10ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211863210.1016/j.ecoenv.2025.118632Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, ChinaTao Zhang0Ran Yan1Xu Zhang2Jianping Ni3Lanlan Fang4Hui Zhao5Yubo Ma6Siyuan Liu7Faming Pan8Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaShanghai Minhang District Center for Disease Control and Prevention, Shanghai 200032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, ChinaShanghai Minhang District Center for Disease Control and Prevention, Shanghai 200032, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; Corresponding author at: Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Background: Short-term exposure to air pollution is strongly associated to cardiovascular disease (CVD) mortality; however, detailed studies in rapidly urbanizing areas remain limited. This study aimed to examine short-term associations between ambient air pollutants and CVD mortality using individual-level data in Hefei City. Methods: We conducted a case-crossover analysis involving 75,230 CVD deaths from 2017 to 2020 in Hefei, China. Individual exposure to fine particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and ozone (O3) was assessed using high-resolution satellite data (1 km resolution). The peak-effect lag days for individual pollutants within a 0–3 day exposure window were identified through conditional logistic regression analysis. Results: Each 10 µg/m3 increase in SO2 (lag 0–2) was associated with a 10.93 % (95 % CI: 6.65 %, 15.39 %) increase in CVD mortality, the strongest effect observed. PM2.5 (lag 0) and NO2 (lag 0–1) were associated with increases of 1.25 % (95 % CI: 0.82 %, 1.68 %) and 2.14 % (95 % CI: 1.38 %, 2.89 %), respectively. For CO (lag 0), each 0.1 mg/m3 increase was linked to a 1.22 % (95 % CI: 0.80 %, 1.64 %) increase in mortality. Other pollutants, including PM10 and O3, also showed weaker but statistically significant associations. Subgroup analyses revealed greater susceptibility among females and during the warm seasons compared to males and cold seasons. Conclusions: Short-term exposure to ambient air pollutants significantly increases CVD mortality risk in Hefei, particularly among females and during warm seasons. These findings underscore the need for targeted public health interventions to mitigate pollution-related cardiovascular risks.http://www.sciencedirect.com/science/article/pii/S0147651325009777Air pollutantsCardiovascular diseaseCase-crossover studyMortalityShort-term exposure |
| spellingShingle | Tao Zhang Ran Yan Xu Zhang Jianping Ni Lanlan Fang Hui Zhao Yubo Ma Siyuan Liu Faming Pan Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China Ecotoxicology and Environmental Safety Air pollutants Cardiovascular disease Case-crossover study Mortality Short-term exposure |
| title | Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China |
| title_full | Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China |
| title_fullStr | Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China |
| title_full_unstemmed | Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China |
| title_short | Association between ambient air pollution and cardiovascular disease mortality: An individual-level case-crossover study in Hefei, China |
| title_sort | association between ambient air pollution and cardiovascular disease mortality an individual level case crossover study in hefei china |
| topic | Air pollutants Cardiovascular disease Case-crossover study Mortality Short-term exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325009777 |
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