MYC target gene activation in chronic lymphocytic leukemia and richter transformation: links to aggressiveness and tumor microenvironment interactions

MYC target gene activation in chronic lymphocytic leukemia and richter transformation: links to aggressiveness and tumor microenvironment interactions

Chronic Lymphocytic Leukemia (CLL) is characterized by clinical and biological heterogeneity, with a subset of patients progressing to Richter Transformation (RT), an aggressive lymphoma. This study explores MYC target gene activation across various CLL stages and disease subgroups using bulk RNAseq...

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Bibliographic Details
Main Authors: M. Tsagiopoulou, S. Rashmi, M. Chatziaslani, I. Gut
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
CLL
MYC
single cell RNAseq
bulk RNAseq
richter transformation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1642458/full
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