Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study

Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study

BackgroundInactivated COVID-19 vaccines exhibit more rapid declines in antibody levels than other vaccine platforms, likely owing to transient antigen exposure and limited germinal center persistence. Moreover, although homologous boosting effectively restores humoral immunity, concerns persist rega...

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Main Authors:	Xinran Song, Weixin Chen, Shuang Bai, Min Lv, Jian Wang, Ao Zhang, Jiang Wu, Wei Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	SARS-CoV-2 inactivated vaccine homologous boosting neutralizing antibodies T cell exhaustion Th1 polarization
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636629/full
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