The characterization of Klebsiella pneumoniae associated with neonatal sepsis in low- and middle-income countries to inform vaccine design

The characterization of Klebsiella pneumoniae associated with neonatal sepsis in low- and middle-income countries to inform vaccine design

Abstract Klebsiella pneumoniae is the leading cause of neonatal sepsis, strongly associated to antimicrobial resistance, with no vaccine available. K-antigens (KAg) have been identified as potential targets, but their diversity makes vaccine development challenging. Alternatively, the use of subcaps...

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Main Authors: Francesca Nonne, Mariagrazia Molfetta, Gianina Florentina Belciug, Martina Carducci, Virginia Cianchi, Casey Zakroff, Salvatore Durante, Caroline Zellmer, Stephen Baker, Thomas D. Stanton, Kathryn E. Holt, Kelly Wyres, Neil Ravenscroft, Gianmarco Gasperini, Omar Rossi, Carlo Giannelli, Francesco Berlanda Scorza, Francesca Micoli
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08258-7
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