Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation
Abstract Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels an...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55478-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559298992242688 |
|---|---|
| author | Yucheng Luo Qiu Yin Keke Chen Zhaoyu Deng Xiaozhou Liu Yinning Zhou Benpeng Zhu Wenming Zhang Zhichao Ma |
| author_facet | Yucheng Luo Qiu Yin Keke Chen Zhaoyu Deng Xiaozhou Liu Yinning Zhou Benpeng Zhu Wenming Zhang Zhichao Ma |
| author_sort | Yucheng Luo |
| collection | DOAJ |
| description | Abstract Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels and the issue of missing embolization. Here, we propose an ultrasound-based method for embolic particle control in submillimeter vessels. The biocompatible ultrasound generated from an extrasomatic source can transmit through biological tissues, and exert forces on the intravital embolic particles. We show that the particles, influenced by these forces, are steerable to the target branch at vascular bifurcations. By modulating the ultrasound to adapt the vascular bifurcation distribution, the particles flowing in the micro-vessel networks are steered to the target branch and embolize it. The acoustic steering within ex vivo and in vivo models both verify the potential of this non-invasive particle control for precise and safe interventional therapy. |
| format | Article |
| id | doaj-art-8c2080d9c7fb4c1ba03dc1672633656d |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-8c2080d9c7fb4c1ba03dc1672633656d2025-01-05T12:38:38ZengNature PortfolioNature Communications2041-17232025-01-0116111210.1038/s41467-024-55478-2Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulationYucheng Luo0Qiu Yin1Keke Chen2Zhaoyu Deng3Xiaozhou Liu4Yinning Zhou5Benpeng Zhu6Wenming Zhang7Zhichao Ma8Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong UniversityInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong UniversityInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong UniversityKey Laboratory of Modern Acoustics, Collaborative Innovation Center of Advanced Microstructures, Institute of Acoustics and School of Physics, Nanjing UniversityKey Laboratory of Modern Acoustics, Collaborative Innovation Center of Advanced Microstructures, Institute of Acoustics and School of Physics, Nanjing UniversityJoint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of MacauSchool of Integrated Circuit, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyState Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong UniversityInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong UniversityAbstract Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels and the issue of missing embolization. Here, we propose an ultrasound-based method for embolic particle control in submillimeter vessels. The biocompatible ultrasound generated from an extrasomatic source can transmit through biological tissues, and exert forces on the intravital embolic particles. We show that the particles, influenced by these forces, are steerable to the target branch at vascular bifurcations. By modulating the ultrasound to adapt the vascular bifurcation distribution, the particles flowing in the micro-vessel networks are steered to the target branch and embolize it. The acoustic steering within ex vivo and in vivo models both verify the potential of this non-invasive particle control for precise and safe interventional therapy.https://doi.org/10.1038/s41467-024-55478-2 |
| spellingShingle | Yucheng Luo Qiu Yin Keke Chen Zhaoyu Deng Xiaozhou Liu Yinning Zhou Benpeng Zhu Wenming Zhang Zhichao Ma Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation Nature Communications |
| title | Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation |
| title_full | Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation |
| title_fullStr | Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation |
| title_full_unstemmed | Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation |
| title_short | Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation |
| title_sort | superselective embolic particle guidance in vessel networks via shape adaptive acoustic manipulation |
| url | https://doi.org/10.1038/s41467-024-55478-2 |
| work_keys_str_mv | AT yuchengluo superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT qiuyin superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT kekechen superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT zhaoyudeng superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT xiaozhouliu superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT yinningzhou superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT benpengzhu superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT wenmingzhang superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation AT zhichaoma superselectiveembolicparticleguidanceinvesselnetworksviashapeadaptiveacousticmanipulation |