Comparison of the effectiveness of high-flow nasal cannula oxygen therapy versus conventional oxygen therapy in preventing extubation failure in children admitted to pediatric intensive care unit in a tertiary care hospital: An open-label randomized control trial
Background: Extubation failure is associated with increased morbidity and mortality. Respiratory support may be needed to prevent extubation failure which can be in the form of conventional oxygen therapy (COT) by nasal prong, face mask, or high-flow nasal cannula (HFNC) or noninvasive ventilation....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Pediatric Critical Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/jpcr/fulltext/2025/03000/comparison_of_the_effectiveness_of_high_flow_nasal.1.aspx |
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| Summary: | Background:
Extubation failure is associated with increased morbidity and mortality. Respiratory support may be needed to prevent extubation failure which can be in the form of conventional oxygen therapy (COT) by nasal prong, face mask, or high-flow nasal cannula (HFNC) or noninvasive ventilation. In our study, we compared the effect of HFNC with COT in preventing extubation failure in children admitted to the pediatric intensive care unit (PICU).
Subjects and Methods:
The study was a single-center open-label randomized control trial done in children after extubation in a tertiary care PICU. All the demographic and clinical details, investigations, and outcomes were recorded in the study proforma. Children included in the study were randomized equally to either receive COT or HFNC. Modified Respiratory Distress Assessment Instrument (mRDAI) was used to gauge the failure or success of the respiratory support.
Results:
A total of 102 children were included in the study with 51 children receiving either COT or HFNC. Reintubation rates did not differ significantly in both groups [HFNC (n = 12, 23.5%) vs. COT (n = 15, 29.4%)]. There was an improvement in mRDAI scores over the treatment period in both study groups. There was no difference in mortality between the two groups.
Conclusions:
There was no difference in extubation failure when HFNC or COT was applied in children after postextubation. |
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| ISSN: | 2349-6592 2455-7099 |