The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218
Marine <i>Streptomyces</i> are an important source of naturally occurring active compounds. Out of 23 marine <i>Streptomyces</i> strains, 1 strain of <i>Streptomyces</i> sp. FJ0218 was selected for its high activity in inhibiting α-glucosidase. Two polyketides, ph...
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2025-04-01
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| author | Pingfa Lin Mianmian Shi Feifei Wang Yong Lin Yongbiao Zheng |
| author_facet | Pingfa Lin Mianmian Shi Feifei Wang Yong Lin Yongbiao Zheng |
| author_sort | Pingfa Lin |
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| description | Marine <i>Streptomyces</i> are an important source of naturally occurring active compounds. Out of 23 marine <i>Streptomyces</i> strains, 1 strain of <i>Streptomyces</i> sp. FJ0218 was selected for its high activity in inhibiting α-glucosidase. Two polyketides, phaeochromycins D (<b>2</b>) and E (<b>1</b>), were isolated from the fermentation broth of this strain using bioactivity-guided column chromatography over RP-18, Sephadex LH-20, and silica gel. Their structures were determined using NMR data, HR-EI-MS, and single-crystal X-ray crystallography. Phaeochromycins D (<b>2</b>) and E (<b>1</b>) exhibited inhibitory activity against α-glucosidase, with IC<sub>50</sub> values of 10 mM and 25 mM, respectively. Lineweaver–Burk plots revealed that phaeochromycin E (<b>1</b>) acts as an uncompetitive inhibitor, while phaeochromycin D (<b>2</b>) acts as a non-competitive inhibitor. These findings suggest that there is potential for the pharmacological regulation of glucose levels through the use of polyketide phaeochromycins, emphasizing their significant impact on glucose management. |
| format | Article |
| id | doaj-art-8c184749d1a540d0980ce71ae5fd1ca9 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-8c184749d1a540d0980ce71ae5fd1ca92025-08-20T02:30:46ZengMDPI AGMolecules1420-30492025-04-01309199310.3390/molecules30091993The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218Pingfa Lin0Mianmian Shi1Feifei Wang2Yong Lin3Yongbiao Zheng4School of Pharmacy, Fujian Health College, Fuzhou 350101, ChinaCollege of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaCollege of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaSchool of Pharmacy, Fujian Health College, Fuzhou 350101, ChinaCollege of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaMarine <i>Streptomyces</i> are an important source of naturally occurring active compounds. Out of 23 marine <i>Streptomyces</i> strains, 1 strain of <i>Streptomyces</i> sp. FJ0218 was selected for its high activity in inhibiting α-glucosidase. Two polyketides, phaeochromycins D (<b>2</b>) and E (<b>1</b>), were isolated from the fermentation broth of this strain using bioactivity-guided column chromatography over RP-18, Sephadex LH-20, and silica gel. Their structures were determined using NMR data, HR-EI-MS, and single-crystal X-ray crystallography. Phaeochromycins D (<b>2</b>) and E (<b>1</b>) exhibited inhibitory activity against α-glucosidase, with IC<sub>50</sub> values of 10 mM and 25 mM, respectively. Lineweaver–Burk plots revealed that phaeochromycin E (<b>1</b>) acts as an uncompetitive inhibitor, while phaeochromycin D (<b>2</b>) acts as a non-competitive inhibitor. These findings suggest that there is potential for the pharmacological regulation of glucose levels through the use of polyketide phaeochromycins, emphasizing their significant impact on glucose management.https://www.mdpi.com/1420-3049/30/9/1993phaeochromycinsα-glucosidase<i>Streptomyces</i> sp. |
| spellingShingle | Pingfa Lin Mianmian Shi Feifei Wang Yong Lin Yongbiao Zheng The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 Molecules phaeochromycins α-glucosidase <i>Streptomyces</i> sp. |
| title | The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 |
| title_full | The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 |
| title_fullStr | The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 |
| title_full_unstemmed | The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 |
| title_short | The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218 |
| title_sort | α glucosidase inhibition activities of phaeochromycins d and e isolated from marine i streptomyces i sp fj0218 |
| topic | phaeochromycins α-glucosidase <i>Streptomyces</i> sp. |
| url | https://www.mdpi.com/1420-3049/30/9/1993 |
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