Correlation of fractional exhalation of nitric oxide values with asthma control test score and spirometric parameters in steroid naïve asthmatic children at 6–8 weeks follow up
Context: In pediatric asthma, it is critical to have a reliable airway inflammation marker that may be used to assess its severity and prognosis. Fractional exhalation of nitric oxide (FeNO) is a non-invasive objective method can be utilized as a supplemental tool if proven to correlate with clinica...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_3_25 |
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| Summary: | Context:
In pediatric asthma, it is critical to have a reliable airway inflammation marker that may be used to assess its severity and prognosis. Fractional exhalation of nitric oxide (FeNO) is a non-invasive objective method can be utilized as a supplemental tool if proven to correlate with clinical parameters.
Aims:
To study the correlation between FeNO, and asthma control test (ACT) scores and spirometry data in steroid naive asthmatic children 6–18 years at visit one and after 6–8 weeks follow-up.
Settings and Design:
This was observational follow-up study conducted among steroid naïve asthmatics attending the Outpatient Department.
Materials and Methods:
At baseline visit, they were classified as well controlled, not well controlled, and poorly controlled as per ACT, FeNO and Spirometry done as per standard technique. After 6–8 weeks of follow-up, all the above parameters were repeated.
Statistical Analysis Used:
Pearson correlation coefficient/Kendall’s tau 2 of 10 analysis was used for the association of two related variables. P <0.05 was considered statistically significant.
Results:
Among 56 enrolled, mean FeNO at visit 1 was 41.8 ± 33.26, which decreased to 20.26 ± 14.57 at visit 2. Changes in mean FeNO values between both visits and ΔACT scores (P = −0.001) and change in forced expiratory volume in 1 sec (ΔFEV1) were statistically significant (P = 0.001). A decrease in FeNO values from baseline was accompanied by significant increase in ACT scores and an improvement in FEV1.
Conclusion:
The FeNO values correlated inversely with the ACT scores as well as FEV1 proving its scope for incorporating it in the clinical setting for monitoring asthma treatment. |
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| ISSN: | 2249-4863 2278-7135 |