Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity
Objective: To determine whether the relationship between cartilage T1ρ relaxation time and age during adolescence and young adulthood is different in hips with Legg–Calvé–Perthes disease (LCPD) deformity compared to hips without LCPD deformity. Design: We recruited 17 participants with LCPD deformit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913125000251 |
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| author | Luke G. Johnson Carly E. Jones Daniel G. Rosenbaum Benjamin Joseph Emily K. Schaeffer Kishore Mulpuri David R. Wilson |
| author_facet | Luke G. Johnson Carly E. Jones Daniel G. Rosenbaum Benjamin Joseph Emily K. Schaeffer Kishore Mulpuri David R. Wilson |
| author_sort | Luke G. Johnson |
| collection | DOAJ |
| description | Objective: To determine whether the relationship between cartilage T1ρ relaxation time and age during adolescence and young adulthood is different in hips with Legg–Calvé–Perthes disease (LCPD) deformity compared to hips without LCPD deformity. Design: We recruited 17 participants with LCPD deformity and 15 control participants aged 10–25 years in this frequency-matched cohort study. Quantitative magnetic resonance images were obtained for both hips in LCPD participants and one hip from each control using a T1ρ MAPSS sequence. The average T1ρ relaxation time in the weight-bearing articular cartilage was calculated, and we tested the interacting effects of age and participant group (LCPD vs non-LCPD) or subgroup (control, contralateral LCPD, spherical LCPD, and aspherical LCPD) on T1ρ using mixed effects models. Results: The main effect of age on T1ρ relaxation time in hips without LCPD deformity was −0.63 ms/year (95 % confidence interval [−0.94, −0.32]). The age-adjusted main effect of LCPD deformity was +2.93 ms [0.65, 3.42] and the interaction effect of age and LCPD deformity was +0.46 ms/year [0.16, 0.76]. Moderate differences were observed between control and contralateral LCPD subgroups, and between spherical LCPD and aspherical LCPD subgroups. Conclusions: Age-related changes in T1ρ relaxation time differ between hips with and without LCPD deformity, suggesting that cartilage degradation in LCPD is progressive and begins early in the healed stage of LCPD. By young adulthood, the difference in T1ρ between LCPD and non-LCPD hips is clinically important when considering osteoarthritis progression and outcomes. |
| format | Article |
| id | doaj-art-8c044ddc8e42407aa5e692f767ea39cb |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-8c044ddc8e42407aa5e692f767ea39cb2025-08-20T01:55:27ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-06-017210058910.1016/j.ocarto.2025.100589Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformityLuke G. Johnson0Carly E. Jones1Daniel G. Rosenbaum2Benjamin Joseph3Emily K. Schaeffer4Kishore Mulpuri5David R. Wilson6School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; Centre for Aging SMART, Vancouver Coastal Health, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Corresponding author. Centre for Aging SMART, 7/F, 2635 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; Centre for Aging SMART, Vancouver Coastal Health, Vancouver, BC, CanadaDepartment of Radiology, University of British Columbia, Vancouver, BC, CanadaDepartment of Paediatric Orthopaedics, Kasturba Medical College, Manipal, Karnataka, IndiaBritish Columbia Children's Hospital Research Institute, Vancouver, BC, CanadaBritish Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, CanadaSchool of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; Centre for Aging SMART, Vancouver Coastal Health, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, CanadaObjective: To determine whether the relationship between cartilage T1ρ relaxation time and age during adolescence and young adulthood is different in hips with Legg–Calvé–Perthes disease (LCPD) deformity compared to hips without LCPD deformity. Design: We recruited 17 participants with LCPD deformity and 15 control participants aged 10–25 years in this frequency-matched cohort study. Quantitative magnetic resonance images were obtained for both hips in LCPD participants and one hip from each control using a T1ρ MAPSS sequence. The average T1ρ relaxation time in the weight-bearing articular cartilage was calculated, and we tested the interacting effects of age and participant group (LCPD vs non-LCPD) or subgroup (control, contralateral LCPD, spherical LCPD, and aspherical LCPD) on T1ρ using mixed effects models. Results: The main effect of age on T1ρ relaxation time in hips without LCPD deformity was −0.63 ms/year (95 % confidence interval [−0.94, −0.32]). The age-adjusted main effect of LCPD deformity was +2.93 ms [0.65, 3.42] and the interaction effect of age and LCPD deformity was +0.46 ms/year [0.16, 0.76]. Moderate differences were observed between control and contralateral LCPD subgroups, and between spherical LCPD and aspherical LCPD subgroups. Conclusions: Age-related changes in T1ρ relaxation time differ between hips with and without LCPD deformity, suggesting that cartilage degradation in LCPD is progressive and begins early in the healed stage of LCPD. By young adulthood, the difference in T1ρ between LCPD and non-LCPD hips is clinically important when considering osteoarthritis progression and outcomes.http://www.sciencedirect.com/science/article/pii/S2665913125000251Legg–Calvé–Perthes diseaseHipQuantitative MRIT1ρ imagingOsteoarthritis |
| spellingShingle | Luke G. Johnson Carly E. Jones Daniel G. Rosenbaum Benjamin Joseph Emily K. Schaeffer Kishore Mulpuri David R. Wilson Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity Osteoarthritis and Cartilage Open Legg–Calvé–Perthes disease Hip Quantitative MRI T1ρ imaging Osteoarthritis |
| title | Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity |
| title_full | Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity |
| title_fullStr | Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity |
| title_full_unstemmed | Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity |
| title_short | Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity |
| title_sort | early age related changes to articular cartilage t1ρ in hips with legg calve perthes disease deformity |
| topic | Legg–Calvé–Perthes disease Hip Quantitative MRI T1ρ imaging Osteoarthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2665913125000251 |
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