First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries

First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries

Abstract Meniscal tears, especially those in avascular regions, pose a significant risk for osteoarthritis if repair fails. While meniscal repair is the preferred method for preserving knee function, it often has a high failure rate in avascular zones. This study aimed to evaluate the safety and pot...

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Bibliographic Details
Main Authors: Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Meniscus tear
Arthroscopic meniscus repair
Artificial protein
Silk-elastin
Needle arthroscope
Knee osteoarthritis
Online Access:https://doi.org/10.1038/s41598-025-88616-x
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