Clinical Course and Outcomes of Late Kidney Allograft Dysfunction
Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predic...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2016/7401808 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850212972175032320 |
|---|---|
| author | Viktor Denisov Vadym Zakharov Anna Ksenofontova Eugene Onishchenko Tatyana Golubova Sergey Kichatyi Olga Zakharova |
| author_facet | Viktor Denisov Vadym Zakharov Anna Ksenofontova Eugene Onishchenko Tatyana Golubova Sergey Kichatyi Olga Zakharova |
| author_sort | Viktor Denisov |
| collection | DOAJ |
| description | Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predict the subsequent duration of the well-functioning of allotransplant the prognostic significance of 15 baseline clinical and sociodemographic characteristics on the results of the survey one year after transplantation was investigated. The result was considered to be positive in constructing the regression prognostication model if recipient lived more than 3 years from the time of transplantation. Results. It was established that more late start of renal allograft dysfunction after transplantation correlates with the more time it takes till complete loss of allograft function. Creatinine and hemoglobin blood concentration and the level of proteinuria one year after transplantation within created mathematical model allow predicting the loss of kidney transplant function three years after the transplantation. Patients with kidney transplant dysfunction are advised to renew the program hemodialysis upon reaching plasma creatinine concentration 0.5–0.7 mmol/L. Conclusion. Values of creatinine, hemoglobin, and proteinuria one year after transplantation can be used for subsequent prognostication of kidney transplant function. |
| format | Article |
| id | doaj-art-8bffc2a66f714fcd990d85aa93e7a978 |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-8bffc2a66f714fcd990d85aa93e7a9782025-08-20T02:09:13ZengWileyJournal of Transplantation2090-00072090-00152016-01-01201610.1155/2016/74018087401808Clinical Course and Outcomes of Late Kidney Allograft DysfunctionViktor Denisov0Vadym Zakharov1Anna Ksenofontova2Eugene Onishchenko3Tatyana Golubova4Sergey Kichatyi5Olga Zakharova6Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineTransplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, UkraineBackground. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predict the subsequent duration of the well-functioning of allotransplant the prognostic significance of 15 baseline clinical and sociodemographic characteristics on the results of the survey one year after transplantation was investigated. The result was considered to be positive in constructing the regression prognostication model if recipient lived more than 3 years from the time of transplantation. Results. It was established that more late start of renal allograft dysfunction after transplantation correlates with the more time it takes till complete loss of allograft function. Creatinine and hemoglobin blood concentration and the level of proteinuria one year after transplantation within created mathematical model allow predicting the loss of kidney transplant function three years after the transplantation. Patients with kidney transplant dysfunction are advised to renew the program hemodialysis upon reaching plasma creatinine concentration 0.5–0.7 mmol/L. Conclusion. Values of creatinine, hemoglobin, and proteinuria one year after transplantation can be used for subsequent prognostication of kidney transplant function.http://dx.doi.org/10.1155/2016/7401808 |
| spellingShingle | Viktor Denisov Vadym Zakharov Anna Ksenofontova Eugene Onishchenko Tatyana Golubova Sergey Kichatyi Olga Zakharova Clinical Course and Outcomes of Late Kidney Allograft Dysfunction Journal of Transplantation |
| title | Clinical Course and Outcomes of Late Kidney Allograft Dysfunction |
| title_full | Clinical Course and Outcomes of Late Kidney Allograft Dysfunction |
| title_fullStr | Clinical Course and Outcomes of Late Kidney Allograft Dysfunction |
| title_full_unstemmed | Clinical Course and Outcomes of Late Kidney Allograft Dysfunction |
| title_short | Clinical Course and Outcomes of Late Kidney Allograft Dysfunction |
| title_sort | clinical course and outcomes of late kidney allograft dysfunction |
| url | http://dx.doi.org/10.1155/2016/7401808 |
| work_keys_str_mv | AT viktordenisov clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT vadymzakharov clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT annaksenofontova clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT eugeneonishchenko clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT tatyanagolubova clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT sergeykichatyi clinicalcourseandoutcomesoflatekidneyallograftdysfunction AT olgazakharova clinicalcourseandoutcomesoflatekidneyallograftdysfunction |