Mechano-regulation of germline development, maintenance, and differentiation
Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somat...
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| Language: | English |
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Elsevier
2024-01-01
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| Series: | BBA Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160324000152 |
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| author | Ishani Sharma Anup Padmanabhan |
| author_facet | Ishani Sharma Anup Padmanabhan |
| author_sort | Ishani Sharma |
| collection | DOAJ |
| description | Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somatic tissues such as those in alveolar, gastrointestinal, embryonic, and skeleto-muscular systems. The germline of an organism has a heterogeneous composition - of germ cells at different stages of maturation and mature gametes, often supported and influenced by their accessory somatic tissues. While biochemical signaling underlying germline functioning has been extensively investigated, a deeper interest in their mechanical regulation has been gaining traction in recent years. In this review, we delve into the myriad ways in which germ cell development, maintenance, and functions are regulated by mechanical forces. |
| format | Article |
| id | doaj-art-8bff047a5fb146788955f2c23f7dca6d |
| institution | OA Journals |
| issn | 2667-1603 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj-art-8bff047a5fb146788955f2c23f7dca6d2025-08-20T01:56:49ZengElsevierBBA Advances2667-16032024-01-01610012710.1016/j.bbadva.2024.100127Mechano-regulation of germline development, maintenance, and differentiationIshani Sharma0Anup Padmanabhan1Department of Biology, Trivedi School of Biosciences, Ashoka University, No. 2 Rajiv Gandhi Educational City, Sonipat, Haryana 131029, IndiaCorresponding author.; Department of Biology, Trivedi School of Biosciences, Ashoka University, No. 2 Rajiv Gandhi Educational City, Sonipat, Haryana 131029, IndiaBiochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somatic tissues such as those in alveolar, gastrointestinal, embryonic, and skeleto-muscular systems. The germline of an organism has a heterogeneous composition - of germ cells at different stages of maturation and mature gametes, often supported and influenced by their accessory somatic tissues. While biochemical signaling underlying germline functioning has been extensively investigated, a deeper interest in their mechanical regulation has been gaining traction in recent years. In this review, we delve into the myriad ways in which germ cell development, maintenance, and functions are regulated by mechanical forces.http://www.sciencedirect.com/science/article/pii/S2667160324000152GermlineMechano-transductionCytoskeletonMechanicsCell adhesionCell fate |
| spellingShingle | Ishani Sharma Anup Padmanabhan Mechano-regulation of germline development, maintenance, and differentiation BBA Advances Germline Mechano-transduction Cytoskeleton Mechanics Cell adhesion Cell fate |
| title | Mechano-regulation of germline development, maintenance, and differentiation |
| title_full | Mechano-regulation of germline development, maintenance, and differentiation |
| title_fullStr | Mechano-regulation of germline development, maintenance, and differentiation |
| title_full_unstemmed | Mechano-regulation of germline development, maintenance, and differentiation |
| title_short | Mechano-regulation of germline development, maintenance, and differentiation |
| title_sort | mechano regulation of germline development maintenance and differentiation |
| topic | Germline Mechano-transduction Cytoskeleton Mechanics Cell adhesion Cell fate |
| url | http://www.sciencedirect.com/science/article/pii/S2667160324000152 |
| work_keys_str_mv | AT ishanisharma mechanoregulationofgermlinedevelopmentmaintenanceanddifferentiation AT anuppadmanabhan mechanoregulationofgermlinedevelopmentmaintenanceanddifferentiation |