Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis
PurposeNumerous prior analyses have highlighted a potential link between androgen suppression therapy (AST) and bladder cancer (BCa). However, there is a notable gap in research specifically examining the influence of finasteride on BCa risk and clinical outcomes. This study aimed to evaluate preven...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1471442/full |
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| author | Ailing Yu Ailing Yu Ailing Yu Ailing Yu Ailing Yu Zian Bai Zian Bai Zian Bai Zian Bai Yijie Wang Yijie Wang Yijie Wang Yijie Wang Zhen Luo Zhen Luo Zhen Luo Zhen Luo Xiaochen Du Mengxin Chen Shuang Wen Honglong Wang Xiaoying Yuan Chunyu Yang Shanshan Bai Bo Fan Bo Fan Bo Fan Bo Fan |
| author_facet | Ailing Yu Ailing Yu Ailing Yu Ailing Yu Ailing Yu Zian Bai Zian Bai Zian Bai Zian Bai Yijie Wang Yijie Wang Yijie Wang Yijie Wang Zhen Luo Zhen Luo Zhen Luo Zhen Luo Xiaochen Du Mengxin Chen Shuang Wen Honglong Wang Xiaoying Yuan Chunyu Yang Shanshan Bai Bo Fan Bo Fan Bo Fan Bo Fan |
| author_sort | Ailing Yu |
| collection | DOAJ |
| description | PurposeNumerous prior analyses have highlighted a potential link between androgen suppression therapy (AST) and bladder cancer (BCa). However, there is a notable gap in research specifically examining the influence of finasteride on BCa risk and clinical outcomes. This study aimed to evaluate preventive and therapeutic value of finasteride for BCa patients.MethodsThis meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched up to 20 December 2024, to identify studies that examined the intake of finasteride and its impact on the incidence and clinical prognosis of patients with BCa. Data was extracted for further analysis by two different reviewers who independently examined the titles and abstracts of the included articles. Subgroup analyses and leave-one-out sensitivity analyses, were applied to mitigate the potential confounding factors associated with heterogeneity.ResultsOur investigation revealed that finasteride markedly decreased the likelihood of developing BCa (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.63–0.88). Subgroup analyses indicated that the preventive effect of finasteride in BCa incidence were generally consistent, regardless of study region, types of research. Furthermore, no notable disparities were observed in OS, CSS, or RFS between the finasteride group and the control group.ConclusionFinasteride plays a protective role against the progression of BCa, nevertheless, its effects on prognostic outcomes, including OS, CSS, and RFS, remain inconclusive. Additional multi-center prospective studies with long-term follow-up are required to further validate prophylactic role of finasteride on bladder cancer.Systematic review registration numberhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=525046, identifier CRD42024525046. |
| format | Article |
| id | doaj-art-8bf9caf3169a4abe90e450f223d76288 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-8bf9caf3169a4abe90e450f223d762882025-01-29T06:45:52ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.14714421471442Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysisAiling Yu0Ailing Yu1Ailing Yu2Ailing Yu3Ailing Yu4Zian Bai5Zian Bai6Zian Bai7Zian Bai8Yijie Wang9Yijie Wang10Yijie Wang11Yijie Wang12Zhen Luo13Zhen Luo14Zhen Luo15Zhen Luo16Xiaochen Du17Mengxin Chen18Shuang Wen19Honglong Wang20Xiaoying Yuan21Chunyu Yang22Shanshan Bai23Bo Fan24Bo Fan25Bo Fan26Bo Fan27Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaLiaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Dalian, Liaoning, ChinaLiaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian, Liaoning, ChinaDalian Key Laboratory of Prostate Cancer Research, Dalian, Liaoning, ChinaFirst Clinical College, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaLiaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Dalian, Liaoning, ChinaLiaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian, Liaoning, ChinaDalian Key Laboratory of Prostate Cancer Research, Dalian, Liaoning, ChinaDepartment of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaLiaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Dalian, Liaoning, ChinaLiaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian, Liaoning, ChinaDalian Key Laboratory of Prostate Cancer Research, Dalian, Liaoning, ChinaDepartment of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaLiaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Dalian, Liaoning, ChinaLiaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian, Liaoning, ChinaDalian Key Laboratory of Prostate Cancer Research, Dalian, Liaoning, ChinaCollege of Humanities and Social Sciences, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Clinical Medicine, First Clinical School of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Pathology, Dalian Friendship Hospital, Dalian, ChinaDepartment of Pathology, Dalian Friendship Hospital, Dalian, ChinaDepartment of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, Liaoning, China0Bidding and procurement office, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China1Department of Ultrasound, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaLiaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Dalian, Liaoning, ChinaLiaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian, Liaoning, ChinaDalian Key Laboratory of Prostate Cancer Research, Dalian, Liaoning, ChinaPurposeNumerous prior analyses have highlighted a potential link between androgen suppression therapy (AST) and bladder cancer (BCa). However, there is a notable gap in research specifically examining the influence of finasteride on BCa risk and clinical outcomes. This study aimed to evaluate preventive and therapeutic value of finasteride for BCa patients.MethodsThis meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched up to 20 December 2024, to identify studies that examined the intake of finasteride and its impact on the incidence and clinical prognosis of patients with BCa. Data was extracted for further analysis by two different reviewers who independently examined the titles and abstracts of the included articles. Subgroup analyses and leave-one-out sensitivity analyses, were applied to mitigate the potential confounding factors associated with heterogeneity.ResultsOur investigation revealed that finasteride markedly decreased the likelihood of developing BCa (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.63–0.88). Subgroup analyses indicated that the preventive effect of finasteride in BCa incidence were generally consistent, regardless of study region, types of research. Furthermore, no notable disparities were observed in OS, CSS, or RFS between the finasteride group and the control group.ConclusionFinasteride plays a protective role against the progression of BCa, nevertheless, its effects on prognostic outcomes, including OS, CSS, and RFS, remain inconclusive. Additional multi-center prospective studies with long-term follow-up are required to further validate prophylactic role of finasteride on bladder cancer.Systematic review registration numberhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=525046, identifier CRD42024525046.https://www.frontiersin.org/articles/10.3389/fphar.2025.1471442/full5-alpha reductase inhibitorsbladder cancerincidencesubgroup analysismeta-analysis |
| spellingShingle | Ailing Yu Ailing Yu Ailing Yu Ailing Yu Ailing Yu Zian Bai Zian Bai Zian Bai Zian Bai Yijie Wang Yijie Wang Yijie Wang Yijie Wang Zhen Luo Zhen Luo Zhen Luo Zhen Luo Xiaochen Du Mengxin Chen Shuang Wen Honglong Wang Xiaoying Yuan Chunyu Yang Shanshan Bai Bo Fan Bo Fan Bo Fan Bo Fan Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis Frontiers in Pharmacology 5-alpha reductase inhibitors bladder cancer incidence subgroup analysis meta-analysis |
| title | Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis |
| title_full | Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis |
| title_fullStr | Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis |
| title_full_unstemmed | Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis |
| title_short | Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis |
| title_sort | impact of finasteride on modulating the risk and clinical outcomes of bladder cancer insights from a comprehensive meta analysis |
| topic | 5-alpha reductase inhibitors bladder cancer incidence subgroup analysis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1471442/full |
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