Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma
Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma. Although it was first described in HIV- (human immunodeficiency virus-) infected patients, PBL has been diagnosed in patients with other immunodeficiencies as well as in immunocompetent patients. PBL immunohistochemically expresses plasmacy...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8876567 |
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| author | Norisato Hashimoto Tomoki Ueda Shinichiro Hiraiwa Takuma Tajiri Naoya Nakamura Kenji Yokoyama |
| author_facet | Norisato Hashimoto Tomoki Ueda Shinichiro Hiraiwa Takuma Tajiri Naoya Nakamura Kenji Yokoyama |
| author_sort | Norisato Hashimoto |
| collection | DOAJ |
| description | Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma. Although it was first described in HIV- (human immunodeficiency virus-) infected patients, PBL has been diagnosed in patients with other immunodeficiencies as well as in immunocompetent patients. PBL immunohistochemically expresses plasmacytic markers and lacks pan B-cell markers. The cells of origin of PBL are considered to be plasmablasts. MYC gene rearrangement and MYC overexpression are frequently found in PBL, but the pathogenesis of PBL is yet to be elucidated. Here, we report a case of composite lymphoma of PBL and diffuse large B-cell lymphoma (DLBCL); that is, PBL in the urinary bladder and DLBCL in the nasal cavity occurred simultaneously. We extracted DNA from the two lymphomas for polymerase chain reaction and sequenced the amplified immunoglobulin heavy variable genes and the complementarity-determining region- (CDR-) 3. The sequence of the CDR3 region of both tumors matched. MYC rearrangement was found in the bladder tumor but not in the nasal tumor. The patient was treated with R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone), and durable remission had been obtained. The results of the DNA analysis indicated that both PBL and DLBCL emerged from common postgerminal B cells. This case may help to elucidate the pathogenesis of PBL. |
| format | Article |
| id | doaj-art-8bef21686afa4297b17c7f60a8302208 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-8bef21686afa4297b17c7f60a83022082025-02-03T06:05:30ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88765678876567Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell LymphomaNorisato Hashimoto0Tomoki Ueda1Shinichiro Hiraiwa2Takuma Tajiri3Naoya Nakamura4Kenji Yokoyama5Department of Hematology/Oncology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 1920032, JapanDepartment of Hematology/Oncology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 1920032, JapanDepartment of Pathology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 1920032, JapanDepartment of Pathology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 1920032, JapanDepartment of Pathology, Tokai University, School of Medicine, 143 Shimokasuya, Isehara 2591193, JapanDepartment of Hematology/Oncology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 1920032, JapanPlasmablastic lymphoma (PBL) is a rare aggressive lymphoma. Although it was first described in HIV- (human immunodeficiency virus-) infected patients, PBL has been diagnosed in patients with other immunodeficiencies as well as in immunocompetent patients. PBL immunohistochemically expresses plasmacytic markers and lacks pan B-cell markers. The cells of origin of PBL are considered to be plasmablasts. MYC gene rearrangement and MYC overexpression are frequently found in PBL, but the pathogenesis of PBL is yet to be elucidated. Here, we report a case of composite lymphoma of PBL and diffuse large B-cell lymphoma (DLBCL); that is, PBL in the urinary bladder and DLBCL in the nasal cavity occurred simultaneously. We extracted DNA from the two lymphomas for polymerase chain reaction and sequenced the amplified immunoglobulin heavy variable genes and the complementarity-determining region- (CDR-) 3. The sequence of the CDR3 region of both tumors matched. MYC rearrangement was found in the bladder tumor but not in the nasal tumor. The patient was treated with R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone), and durable remission had been obtained. The results of the DNA analysis indicated that both PBL and DLBCL emerged from common postgerminal B cells. This case may help to elucidate the pathogenesis of PBL.http://dx.doi.org/10.1155/2020/8876567 |
| spellingShingle | Norisato Hashimoto Tomoki Ueda Shinichiro Hiraiwa Takuma Tajiri Naoya Nakamura Kenji Yokoyama Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma Case Reports in Hematology |
| title | Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma |
| title_full | Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma |
| title_fullStr | Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma |
| title_short | Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma |
| title_sort | clonally related plasmablastic lymphoma simultaneously occurring with diffuse large b cell lymphoma |
| url | http://dx.doi.org/10.1155/2020/8876567 |
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