Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.

Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.

Neonatal pain-related stress is associated with elevated salivary cortisol levels to age 18 months in children born very preterm, compared to full-term, suggesting early programming effects. Importantly, interactions between immune/inflammatory and neuroendocrine systems may underlie programming eff...

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Main Authors: Ruth E Grunau, Ivan L Cepeda, Cecil M Y Chau, Susanne Brummelte, Joanne Weinberg, Pascal M Lavoie, Mihoko Ladd, Aaron F Hirschfeld, Evan Russell, Gideon Koren, Stan Van Uum, Rollin Brant, Stuart E Turvey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0073926
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