Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis

Several studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects inclu...

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Main Authors: Tuerhongjiang Tuxun, Hai-Zhang Ma, Shadike Apaer, Heng Zhang, Amina Aierken, Yu-Peng Li, Ren-Yong Lin, Jin-Ming Zhao, Jin-Hui Zhang, Hao Wen
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/632760
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author Tuerhongjiang Tuxun
Hai-Zhang Ma
Shadike Apaer
Heng Zhang
Amina Aierken
Yu-Peng Li
Ren-Yong Lin
Jin-Ming Zhao
Jin-Hui Zhang
Hao Wen
author_facet Tuerhongjiang Tuxun
Hai-Zhang Ma
Shadike Apaer
Heng Zhang
Amina Aierken
Yu-Peng Li
Ren-Yong Lin
Jin-Ming Zhao
Jin-Hui Zhang
Hao Wen
author_sort Tuerhongjiang Tuxun
collection DOAJ
description Several studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects including AE group (N=28), CE group (N=22), and healthy controls (HC, N=28) were enrolled in this study. The mRNA expression levels of TLR2 and TLR4 in blood and hepatic tissue and plasma levels related cytokines were detected by using ELISA. Median levels of TLR2 mRNA in AE and CE groups were significantly elevated as compared with that in healthy control group. Median levels of TLR4 expression were increased in AE and CE. Plasma concentration levels of IL-5, IL-6, and IL-10 were slightly increased in AE and CE groups compared with those in HC group with no statistical differences (p>0.05). The IL-23 concentration levels were significantly higher in AE and CE groups than that in HC subjects with statistical significance. The increased expression of TLR2 and IL-23 might play a potential role in modulating tissue infiltrative growth of the parasite and its persistence in the human host.
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institution Kabale University
issn 0962-9351
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language English
publishDate 2015-01-01
publisher Wiley
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series Mediators of Inflammation
spelling doaj-art-8be95af4c071417282116519d4fe73532025-02-03T06:13:39ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/632760632760Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar EchinococcosisTuerhongjiang Tuxun0Hai-Zhang Ma1Shadike Apaer2Heng Zhang3Amina Aierken4Yu-Peng Li5Ren-Yong Lin6Jin-Ming Zhao7Jin-Hui Zhang8Hao Wen9State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaDepartment of Ultrasonography, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaDepartment of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaSeveral studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects including AE group (N=28), CE group (N=22), and healthy controls (HC, N=28) were enrolled in this study. The mRNA expression levels of TLR2 and TLR4 in blood and hepatic tissue and plasma levels related cytokines were detected by using ELISA. Median levels of TLR2 mRNA in AE and CE groups were significantly elevated as compared with that in healthy control group. Median levels of TLR4 expression were increased in AE and CE. Plasma concentration levels of IL-5, IL-6, and IL-10 were slightly increased in AE and CE groups compared with those in HC group with no statistical differences (p>0.05). The IL-23 concentration levels were significantly higher in AE and CE groups than that in HC subjects with statistical significance. The increased expression of TLR2 and IL-23 might play a potential role in modulating tissue infiltrative growth of the parasite and its persistence in the human host.http://dx.doi.org/10.1155/2015/632760
spellingShingle Tuerhongjiang Tuxun
Hai-Zhang Ma
Shadike Apaer
Heng Zhang
Amina Aierken
Yu-Peng Li
Ren-Yong Lin
Jin-Ming Zhao
Jin-Hui Zhang
Hao Wen
Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
Mediators of Inflammation
title Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
title_full Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
title_fullStr Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
title_full_unstemmed Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
title_short Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
title_sort expression of toll like receptors 2 and 4 and related cytokines in patients with hepatic cystic and alveolar echinococcosis
url http://dx.doi.org/10.1155/2015/632760
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