Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

Abstract Differentiation of induced pluripotent stem cells (iPSCs) into specialized cell types is essential for uncovering cell-type specific molecular mechanisms and interrogating cellular function. Transcription factor screens have enabled efficient production of a few cell types; however, enginee...

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Main Authors: Songlei Liu, Li Li, Fan Zhang, Mariana Garcia-Corral, Katharina Meyer, Patrick R. J. Fortuna, Björn van Sambeek, Evan Appleton, Alex H. M. Ng, Parastoo Khoshakhlagh, Yuancheng Ryan Lu, James Cameron, Ricardo N. Ramirez, Yuting Chen, Chun-Ting Wu, Jeremy Y. Huang, Yuqi Tan, George Chao, John Aach, Elaine T. Lim, Jenny M. Tam, Soumya Raychaudhuri, George M. Church
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59596-3
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