Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs

Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs

Summary: The ribonuclease DIS3 interacts through its PIN domain with the nuclear exosome and degrades linear RNA substrates using its exoribonuclease domain. However, the PIN domain is also an active endoribonuclease, but cellular substrates are largely unknown. Here, we use a biochemical strategy t...

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Bibliographic Details
Main Authors: Claudia Latini, Julian Eichlinger, Anna-Lisa Fuchs, Si-Nan Zhai, Hung Ho-Xuan, Gerhard Lehmann, Petar Glažar, Nikolaus Rajewsky, Astrid Bruckmann, Li Yang, Remco Sprangers, Gunter Meister
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005406
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