Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature
Sorafenib is a novel small molecule multiple kinase inhibitor which has been used for metastatic renal cancer, hepatocellular cancer. Sorafenib induced skin rash has been discussed as a side effect in trials in both FLT3 wild type and mutated acute myeloid leukemia (AML) as monotherapy or as combina...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/1399 |
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| author | Jayastu Senapati Anup J Devasia Abhijeet Ganapule Leni George Auro Viswabandya |
| author_facet | Jayastu Senapati Anup J Devasia Abhijeet Ganapule Leni George Auro Viswabandya |
| author_sort | Jayastu Senapati |
| collection | DOAJ |
| description | Sorafenib is a novel small molecule multiple kinase inhibitor which has been used for metastatic renal cancer, hepatocellular cancer. Sorafenib induced skin rash has been discussed as a side effect in trials in both FLT3 wild type and mutated acute myeloid leukemia (AML) as monotherapy or as combination with other chemotherapeutic agents . We describe a patient with FLT 3 ITD mutated AML who was started on adjunctive Sorafenib therapy. Skin reactions manifested as NCI Grade III palmoplantar erythrodysesthesia (PPE), requiring drug discontinuation. Several pathogenic mechanisms have been implicated in Sorafenib induced skin reactions, but none has been conclusively proven. While treatment options are varied for early stage skin reactions, drug discontinuation remains the only possible therapy presently for severe grade skin reaction. |
| format | Article |
| id | doaj-art-8be49e90e2c34ed795e23828e73d027d |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-8be49e90e2c34ed795e23828e73d027d2025-08-20T02:08:35ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-02-0161e2014016e201401610.4084/mjhid.2014.0161159Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literatureJayastu Senapati0Anup J Devasia1Abhijeet Ganapule2Leni George3Auro Viswabandya4Department of Clinical Haematology, Christian Medical College and Hospital,VelloreDepartment of Clinical Haematology, Christian Medical College and Hospital VelloreDepartment of Clinical Haematology, Christian Medical College and Hospital,VelloreDepartment of Dermatology, Christian Medical College and Hospital VelloreDepartment of Clinical Haematology, Christian Medical College and Hospital, VelloreSorafenib is a novel small molecule multiple kinase inhibitor which has been used for metastatic renal cancer, hepatocellular cancer. Sorafenib induced skin rash has been discussed as a side effect in trials in both FLT3 wild type and mutated acute myeloid leukemia (AML) as monotherapy or as combination with other chemotherapeutic agents . We describe a patient with FLT 3 ITD mutated AML who was started on adjunctive Sorafenib therapy. Skin reactions manifested as NCI Grade III palmoplantar erythrodysesthesia (PPE), requiring drug discontinuation. Several pathogenic mechanisms have been implicated in Sorafenib induced skin reactions, but none has been conclusively proven. While treatment options are varied for early stage skin reactions, drug discontinuation remains the only possible therapy presently for severe grade skin reaction.http://www.mjhid.org/index.php/mjhid/article/view/1399Sorafenib, Hand Foot Skin Rash,FLT3, Acute Myeloid Leukemia. |
| spellingShingle | Jayastu Senapati Anup J Devasia Abhijeet Ganapule Leni George Auro Viswabandya Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature Mediterranean Journal of Hematology and Infectious Diseases Sorafenib, Hand Foot Skin Rash, FLT3, Acute Myeloid Leukemia. |
| title | Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature |
| title_full | Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature |
| title_fullStr | Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature |
| title_full_unstemmed | Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature |
| title_short | Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature |
| title_sort | sorafenib induced hand foot skin rash in flt3 itd mutated acute myeloid leukemia a case report and review of literature |
| topic | Sorafenib, Hand Foot Skin Rash, FLT3, Acute Myeloid Leukemia. |
| url | http://www.mjhid.org/index.php/mjhid/article/view/1399 |
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