Fibrillary glomerulopathy:one case report and literature review
Objective To discuss the mechanism,clinical feature,diagnosis,treatment and prognosis of fibrillary glomerulopathy（FGP） by analyzing a patient with FGP.Methods The clinical manifestations of a 21-year old patient diagnosed with FGP were studied.The renopuncture biopsy tissues of this patient were ob...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57921019&Fpath=home&index=0 |
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| Summary: | Objective To discuss the mechanism,clinical feature,diagnosis,treatment and prognosis of fibrillary glomerulopathy（FGP） by analyzing a patient with FGP.Methods The clinical manifestations of a 21-year old patient diagnosed with FGP were studied.The renopuncture biopsy tissues of this patient were observed by light microscope with staining,fluorescent staining and electron microscope.According to the data we studied above,we summarized the characteristics of FGP,and reviewed the related literatures.Results The diagnosis of FGP depended on the following conditions,clinical manifestations,renal histopathological examination,and above all electron microscope.Most patients presented with nephrotic proteinuria,hematuria and hypertension.Electron miacroscope was the main diagnosis basis for FGP,which showed that glomerular mesangial area and glomerular basement membrane were infiltrated by randomly arranged,stiff,nonbranching fibrils.Owing to poor diagnosis,most patients developed to end-stage renal disease within a few years.Conclusions Electron microscopy combined with Congo red staining plays an important role in the diagnosis of FGP.FGP possesses such features as low incidence of the disease,the ambiguity of the pathophysiological mechanisms and poor prognosis,which makes the disease lack of effective treatment measures. |
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| ISSN: | 1671-2390 |