Helicobacter Pylori in Patients with Chronic Immune Thrombocytopenic Purpura: A Pilot Study
Background: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder. Children with chronic ITP were reported to be at higher risk of associated Helicobacter pylori (H. pylori) infection. Aim of the work: To identify the frequency of H. pylori infection among children with chronic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cairo University, Faculty of Medicine, Department of Pediatrics
2025-07-01
|
| Series: | Pediatric Sciences Journal |
| Subjects: | |
| Online Access: | https://cupsj.journals.ekb.eg/article_434770_00dbbd7b53251d5745c89e02c15ef857.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder.
Children with chronic ITP were reported to be at higher risk of associated Helicobacter pylori (H.
pylori) infection.
Aim of the work: To identify the frequency of H. pylori infection among children with chronic
ITP.
Subjects and Methods: This cross-sectional observational study included 70 children with
chronic ITP and a control group consisted of healthy 60 children of similar age and sex. They all
underwent enzymatic immunoassay (EIA) stool antigen test (SAT) for H. pylori.
Results: The group with chronic ITP included 40 (57.1%) males and 30 (42.9%) females, while
the control group included 30 (50%) males and 30 (50%) females (p=0.47). The mean ± SD age of
the cases and control group was 10.5 ± 6.5 years and 10.3 ± 4.2years (p=0.44). The mean ± SD
duration of ITP was 15.8 ± 5.6 months. All patients were on corticosteroid therapy. Only 10
(14.3%) of the cases with ITP underwent splenectomy. There was no statistical difference in the
rates of H. pylori among those with ITP and the control group. Among the 70 children with a
chronic ITP, 20 (28.6 %) had H. pylori, compared to 11 (19%) of the control group (p=0.172). The
rate of H. pylori infection correlated with longer duration of ITP (p-value = 0.03).
Conclusion: Despite an apparent increase in rate of H. pylori among those with chronic ITP
compared to the control group, it did not mount to statistical significance. Children with chronic
ITP do not seem to be more vulnerable than their healthy peers to H. pylori. Further studies of
the effect of H. pylori treatment on chronic ITP are recommended. |
|---|---|
| ISSN: | 2805-279X 2682-3985 |