Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization

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Main Authors: Sven Tiedemann, Annabel Stang, Simon Last, Thierry Gefflaut, Jan von Langermann
Format: Article
Language:English
Published: American Chemical Society 2025-04-01
Series:ACS Omega
Online Access:https://doi.org/10.1021/acsomega.5c00590
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author Sven Tiedemann
Annabel Stang
Simon Last
Thierry Gefflaut
Jan von Langermann
author_facet Sven Tiedemann
Annabel Stang
Simon Last
Thierry Gefflaut
Jan von Langermann
author_sort Sven Tiedemann
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format Article
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institution OA Journals
issn 2470-1343
language English
publishDate 2025-04-01
publisher American Chemical Society
record_format Article
series ACS Omega
spelling doaj-art-8bcd8b76f2344ddba646fed9d2a771cc2025-08-20T02:16:10ZengAmerican Chemical SocietyACS Omega2470-13432025-04-011014143821438910.1021/acsomega.5c00590Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and CyclizationSven Tiedemann0Annabel Stang1Simon Last2Thierry Gefflaut3Jan von Langermann4Institute of Chemistry, Biocatalysis Group, Otto von Guericke University Magdeburg, Magdeburg, GermanyInstitute of Chemistry, Biocatalysis Group, Otto von Guericke University Magdeburg, Magdeburg, GermanyInstitute of Chemistry, Biocatalysis Group, Otto von Guericke University Magdeburg, Magdeburg, GermanyInstitut de Chimie de Clermont-Ferrand, Université Clermont Auvergne, Aubiere Cedex, FranceInstitute of Chemistry, Biocatalysis Group, Otto von Guericke University Magdeburg, Magdeburg, Germanyhttps://doi.org/10.1021/acsomega.5c00590
spellingShingle Sven Tiedemann
Annabel Stang
Simon Last
Thierry Gefflaut
Jan von Langermann
Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
ACS Omega
title Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
title_full Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
title_fullStr Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
title_full_unstemmed Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
title_short Preparative Coupled Enzymatic Synthesis of L‑Homophenylalanine and 2‑Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization
title_sort preparative coupled enzymatic synthesis of l homophenylalanine and 2 hydroxy 5 oxoproline with direct in situ product crystallization and cyclization
url https://doi.org/10.1021/acsomega.5c00590
work_keys_str_mv AT sventiedemann preparativecoupledenzymaticsynthesisoflhomophenylalanineand2hydroxy5oxoprolinewithdirectinsituproductcrystallizationandcyclization
AT annabelstang preparativecoupledenzymaticsynthesisoflhomophenylalanineand2hydroxy5oxoprolinewithdirectinsituproductcrystallizationandcyclization
AT simonlast preparativecoupledenzymaticsynthesisoflhomophenylalanineand2hydroxy5oxoprolinewithdirectinsituproductcrystallizationandcyclization
AT thierrygefflaut preparativecoupledenzymaticsynthesisoflhomophenylalanineand2hydroxy5oxoprolinewithdirectinsituproductcrystallizationandcyclization
AT janvonlangermann preparativecoupledenzymaticsynthesisoflhomophenylalanineand2hydroxy5oxoprolinewithdirectinsituproductcrystallizationandcyclization