Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study.
<h4>Background</h4>It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cogni...
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Public Library of Science (PLoS)
2016-01-01
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| author | Remko Kockelkoren Jill B De Vis Willem P Th M Mali Jeroen Hendrikse Pim A de Jong Annemieke M Rozemuller Huiberdina L Koek |
| author_facet | Remko Kockelkoren Jill B De Vis Willem P Th M Mali Jeroen Hendrikse Pim A de Jong Annemieke M Rozemuller Huiberdina L Koek |
| author_sort | Remko Kockelkoren |
| collection | DOAJ |
| description | <h4>Background</h4>It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cognition and cognitive decline. Therefore, the aim of this study was to (1) determine the prevalence of hippocampal calcification on CT in memory clinic patients controls, and (2) to assess its relation with cognitive decline.<h4>Methods</h4>67 patients from a memory clinic (cases) were matched by age and gender to a control group. In both groups, hippocampal calcification was assessed by two raters on thin slice, non-contrast enhanced brain CT images. Calcifications were scored bilaterally on presence and severity (absent, mild, moderate, severe). Mini Mental State Exam (MMSE) score was determined in cases.<h4>Results</h4>Hippocampal calcification presence was significantly higher in cases (N = 26, 38.8%) compared to controls (N = 9, 13.4%) (P < .01) with an odds ratio of 4.40 (95%CI: 1.63-14.87). In cases, MMSE score was significantly lower in those with hippocampal calcification compared to those without (21.6 vs 24.5, p = .02).<h4>Conclusion</h4>In this case-control study we found significantly more hippocampal calcification in patients with cognitive decline as compared to controls. Furthermore, within the cases, MMSE score was significantly lower in those with hippocampal calcification. |
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| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-8bc3fe3535da4cc08e91b7b01ea1e5bb2025-08-20T02:03:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016744410.1371/journal.pone.0167444Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study.Remko KockelkorenJill B De VisWillem P Th M MaliJeroen HendriksePim A de JongAnnemieke M RozemullerHuiberdina L Koek<h4>Background</h4>It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cognition and cognitive decline. Therefore, the aim of this study was to (1) determine the prevalence of hippocampal calcification on CT in memory clinic patients controls, and (2) to assess its relation with cognitive decline.<h4>Methods</h4>67 patients from a memory clinic (cases) were matched by age and gender to a control group. In both groups, hippocampal calcification was assessed by two raters on thin slice, non-contrast enhanced brain CT images. Calcifications were scored bilaterally on presence and severity (absent, mild, moderate, severe). Mini Mental State Exam (MMSE) score was determined in cases.<h4>Results</h4>Hippocampal calcification presence was significantly higher in cases (N = 26, 38.8%) compared to controls (N = 9, 13.4%) (P < .01) with an odds ratio of 4.40 (95%CI: 1.63-14.87). In cases, MMSE score was significantly lower in those with hippocampal calcification compared to those without (21.6 vs 24.5, p = .02).<h4>Conclusion</h4>In this case-control study we found significantly more hippocampal calcification in patients with cognitive decline as compared to controls. Furthermore, within the cases, MMSE score was significantly lower in those with hippocampal calcification.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167444&type=printable |
| spellingShingle | Remko Kockelkoren Jill B De Vis Willem P Th M Mali Jeroen Hendrikse Pim A de Jong Annemieke M Rozemuller Huiberdina L Koek Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. PLoS ONE |
| title | Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. |
| title_full | Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. |
| title_fullStr | Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. |
| title_full_unstemmed | Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. |
| title_short | Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study. |
| title_sort | hippocampal calcification on computed tomography in relation to cognitive decline in memory clinic patients a case control study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167444&type=printable |
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