Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy
Abstract Thyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, p...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02263-4 |
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| author | Yuxuan Wan Guoqing Li Gaoyuan Cui Saili Duan Shi Chang |
| author_facet | Yuxuan Wan Guoqing Li Gaoyuan Cui Saili Duan Shi Chang |
| author_sort | Yuxuan Wan |
| collection | DOAJ |
| description | Abstract Thyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment. In this review, we initiatively summarize recent progress in the full-scale thyroid cancer metabolic rewiring and the interconnection of various metabolites. We also discuss the efficacy and prospect of metabolic targeted detection as well as therapy. Comprehending metabolic mechanism and characteristics of thyroid cancer roundly will be highly beneficial to managing individual patients. |
| format | Article |
| id | doaj-art-8bbbad7a3bbe4c8a8dec5202770dfb2c |
| institution | DOAJ |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-8bbbad7a3bbe4c8a8dec5202770dfb2c2025-08-20T02:56:16ZengBMCMolecular Cancer1476-45982025-03-0124113010.1186/s12943-025-02263-4Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic StrategyYuxuan Wan0Guoqing Li1Gaoyuan Cui2Saili Duan3Shi Chang4Department of General Surgery, Xiangya Hospital Central South UniversityDepartment of General Surgery, Xiangya Hospital Central South UniversityXiangya School of Medicine, Central South UniversityDepartment of General Surgery, Xiangya Hospital Central South UniversityDepartment of General Surgery, Xiangya Hospital Central South UniversityAbstract Thyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment. In this review, we initiatively summarize recent progress in the full-scale thyroid cancer metabolic rewiring and the interconnection of various metabolites. We also discuss the efficacy and prospect of metabolic targeted detection as well as therapy. Comprehending metabolic mechanism and characteristics of thyroid cancer roundly will be highly beneficial to managing individual patients.https://doi.org/10.1186/s12943-025-02263-4Thyroid cancerMetabolismGeneticsCarcinogenesisDiagnosisTargeted therapy |
| spellingShingle | Yuxuan Wan Guoqing Li Gaoyuan Cui Saili Duan Shi Chang Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy Molecular Cancer Thyroid cancer Metabolism Genetics Carcinogenesis Diagnosis Targeted therapy |
| title | Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy |
| title_full | Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy |
| title_fullStr | Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy |
| title_full_unstemmed | Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy |
| title_short | Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy |
| title_sort | reprogramming of thyroid cancer metabolism from mechanism to therapeutic strategy |
| topic | Thyroid cancer Metabolism Genetics Carcinogenesis Diagnosis Targeted therapy |
| url | https://doi.org/10.1186/s12943-025-02263-4 |
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