Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma

Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma

BackgroundThe tumor nests in solid tumors, including hepatocellular carcinoma (HCC), possess tumor-initiating potential, with the capacity to metastasize and form new metastatic lesions. However, the biological characteristics and heterogeneity of tumor cells at the central and marginal regions of t...

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Bibliographic Details
Main Authors: Ziyi Li, Yikai Hu, Zhuotian He, Heyi Xu, Hongyang Wang, Yufei He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
tumor nest
spatial transcriptomic
fibrotic nodules
heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1611951/full
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