Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports
Bone scintigraphy with technetium-labelled diphosphonates is widely used for evaluating skeletal pathology. However, extra-osseous uptake may also be encountered and can indicate underlying neoplastic processes. We report 2 cases of incidental intra-abdominal uptake on bone scans, later confirmed as...
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Elsevier
2025-10-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325006454 |
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| author | Gary Ka Wai Chan, MBChB Tsz Kit Chow, MBBS, FHKCR Yan Ho Hui, MBChB, FHKCR Wai Yin Ho, MBBS, FHKCR |
| author_facet | Gary Ka Wai Chan, MBChB Tsz Kit Chow, MBBS, FHKCR Yan Ho Hui, MBChB, FHKCR Wai Yin Ho, MBBS, FHKCR |
| author_sort | Gary Ka Wai Chan, MBChB |
| collection | DOAJ |
| description | Bone scintigraphy with technetium-labelled diphosphonates is widely used for evaluating skeletal pathology. However, extra-osseous uptake may also be encountered and can indicate underlying neoplastic processes. We report 2 cases of incidental intra-abdominal uptake on bone scans, later confirmed as gastrointestinal stromal tumors. In both cases, planar bone scintigraphy revealed focal tracer uptake in the abdomen, which SPECT/CT localized to exophytic gastric masses with intralesional calcification. Histopathological confirmation was obtained via endoscopic biopsy and surgical resection. These cases highlight the diagnostic value of hybrid SPECT/CT imaging in evaluating unexpected soft tissue uptake, enabling accurate anatomical localization and differentiation from physiological or benign causes. Although the mechanisms of diphosphonate accumulation in extra-osseous neoplasms are not fully understood, contributing factors may include calcification, vascularity, and altered tissue microenvironment. Recognition of such findings can facilitate timely diagnosis and management. Awareness of neoplastic causes of extra-osseous uptake is essential for interpreting physicians to guide appropriate clinical follow-up. |
| format | Article |
| id | doaj-art-8bb40c52638845138152de205bf159f4 |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-8bb40c52638845138152de205bf159f42025-08-20T02:47:03ZengElsevierRadiology Case Reports1930-04332025-10-0120105061506410.1016/j.radcr.2025.06.096Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reportsGary Ka Wai Chan, MBChB0Tsz Kit Chow, MBBS, FHKCR1Yan Ho Hui, MBChB, FHKCR2Wai Yin Ho, MBBS, FHKCR3Nuclear Medicine Unit, Department of Radiology, Queen Mary Hospital, Hong Kong; Corresponding author.Nuclear Medicine Unit, Department of Radiology and Nuclear Medicine, Tuen Mun Hospital, Hong KongNuclear Medicine Unit, Department of Radiology, Queen Mary Hospital, Hong KongNuclear Medicine Unit, Department of Radiology, Queen Mary Hospital, Hong KongBone scintigraphy with technetium-labelled diphosphonates is widely used for evaluating skeletal pathology. However, extra-osseous uptake may also be encountered and can indicate underlying neoplastic processes. We report 2 cases of incidental intra-abdominal uptake on bone scans, later confirmed as gastrointestinal stromal tumors. In both cases, planar bone scintigraphy revealed focal tracer uptake in the abdomen, which SPECT/CT localized to exophytic gastric masses with intralesional calcification. Histopathological confirmation was obtained via endoscopic biopsy and surgical resection. These cases highlight the diagnostic value of hybrid SPECT/CT imaging in evaluating unexpected soft tissue uptake, enabling accurate anatomical localization and differentiation from physiological or benign causes. Although the mechanisms of diphosphonate accumulation in extra-osseous neoplasms are not fully understood, contributing factors may include calcification, vascularity, and altered tissue microenvironment. Recognition of such findings can facilitate timely diagnosis and management. Awareness of neoplastic causes of extra-osseous uptake is essential for interpreting physicians to guide appropriate clinical follow-up.http://www.sciencedirect.com/science/article/pii/S1930043325006454Gastrointestinal stromal tumorAbdominal neoplasmBone scintigraphySPECT/CT scan |
| spellingShingle | Gary Ka Wai Chan, MBChB Tsz Kit Chow, MBBS, FHKCR Yan Ho Hui, MBChB, FHKCR Wai Yin Ho, MBBS, FHKCR Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports Radiology Case Reports Gastrointestinal stromal tumor Abdominal neoplasm Bone scintigraphy SPECT/CT scan |
| title | Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports |
| title_full | Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports |
| title_fullStr | Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports |
| title_full_unstemmed | Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports |
| title_short | Incidental finding of bone tracer accumulation in gastrointestinal stromal tumor: Two case reports |
| title_sort | incidental finding of bone tracer accumulation in gastrointestinal stromal tumor two case reports |
| topic | Gastrointestinal stromal tumor Abdominal neoplasm Bone scintigraphy SPECT/CT scan |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325006454 |
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