A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection
PurposeThis investigation aimed to create a new nomogram based on complement C3 to forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery.MethodsThis study encompassed 1234 pati...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1559083/full |
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| author | Guoyi Xia Guoyi Xia Zeyan Yu Shaolong Lu Xiaobo Wang Yuanquan Zhao Jie Chen |
| author_facet | Guoyi Xia Guoyi Xia Zeyan Yu Shaolong Lu Xiaobo Wang Yuanquan Zhao Jie Chen |
| author_sort | Guoyi Xia |
| collection | DOAJ |
| description | PurposeThis investigation aimed to create a new nomogram based on complement C3 to forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery.MethodsThis study encompassed 1234 patients treated with resection at the Affiliated Cancer Hospital of Guangxi Medical University. The cohort for primary included 865 patients from December 2015 to December 2019, while the validation cohort comprised 369 patients. Follow-ups were conducted regularly until December 2024. Variables predicting survival were identified using Cox regression analyses, and based on these, a nomogram was constructed. This nomogram’s accuracy was assessed via time-dependent ROC curves, calibration curves and KM curve analyses.ResultsInvestigations identified complement C3, PT, the presence of cirrhosis, tumor capsule, and MVI-M2 as distinct predictors of survival in HCC patients. Based on these findings, a predictive nomogram was constructed and validated, aimed at estimating the 1-, 3-, and 5-year OS. The efficacy of the nomogram was validated through analyses with ROC curves, calibration curves, each demonstrating positive outcomes. Additionally, KM curve analysis effectively separated the patient populations into two prognostic risk categories within both the primary and validation cohorts.ConclusionIn conclusion, a new nomogram has been developed and corroborated through multivariate Cox regression analysis, aimed at estimating overall survival for patients in early stages of microvascular invasion following surgical resection. This tool has proven to be more effective in forecasting survival outcomes for such patients post-curative surgery. |
| format | Article |
| id | doaj-art-8bb3d42f4ad74398b7eb0b548b151372 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-8bb3d42f4ad74398b7eb0b548b1513722025-08-20T02:14:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15590831559083A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resectionGuoyi Xia0Guoyi Xia1Zeyan Yu2Shaolong Lu3Xiaobo Wang4Yuanquan Zhao5Jie Chen6Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Hepatobiliary Surgery, The Central Hospital of Shaoyang, Shaoyang, Hunan, ChinaDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Hepatobiliary Surgery, Guangxi Zhuang Autonomous Region People’s Hospital, Nanning, Guangxi, ChinaDepartment of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaPurposeThis investigation aimed to create a new nomogram based on complement C3 to forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery.MethodsThis study encompassed 1234 patients treated with resection at the Affiliated Cancer Hospital of Guangxi Medical University. The cohort for primary included 865 patients from December 2015 to December 2019, while the validation cohort comprised 369 patients. Follow-ups were conducted regularly until December 2024. Variables predicting survival were identified using Cox regression analyses, and based on these, a nomogram was constructed. This nomogram’s accuracy was assessed via time-dependent ROC curves, calibration curves and KM curve analyses.ResultsInvestigations identified complement C3, PT, the presence of cirrhosis, tumor capsule, and MVI-M2 as distinct predictors of survival in HCC patients. Based on these findings, a predictive nomogram was constructed and validated, aimed at estimating the 1-, 3-, and 5-year OS. The efficacy of the nomogram was validated through analyses with ROC curves, calibration curves, each demonstrating positive outcomes. Additionally, KM curve analysis effectively separated the patient populations into two prognostic risk categories within both the primary and validation cohorts.ConclusionIn conclusion, a new nomogram has been developed and corroborated through multivariate Cox regression analysis, aimed at estimating overall survival for patients in early stages of microvascular invasion following surgical resection. This tool has proven to be more effective in forecasting survival outcomes for such patients post-curative surgery.https://www.frontiersin.org/articles/10.3389/fonc.2025.1559083/fullhepatocellular carcinomaearly-stagemicrovascular invasioncurative resectionoverall survival |
| spellingShingle | Guoyi Xia Guoyi Xia Zeyan Yu Shaolong Lu Xiaobo Wang Yuanquan Zhao Jie Chen A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection Frontiers in Oncology hepatocellular carcinoma early-stage microvascular invasion curative resection overall survival |
| title | A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection |
| title_full | A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection |
| title_fullStr | A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection |
| title_full_unstemmed | A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection |
| title_short | A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection |
| title_sort | novel nomogram based on complement c3 to predict the overall survival of early stage hepatocellular carcinoma patients with microvascular invasion positive undergoing curative resection |
| topic | hepatocellular carcinoma early-stage microvascular invasion curative resection overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1559083/full |
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