Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer
Abstract The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutroph...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-05010-3 |
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| author | Emiri Miyamoto Masato Yoshihara Shohei Iyoshi Kazumasa Mogi Kaname Uno Hiroki Fujimoto Yoshihiro Koya Kazuhisa Kitami Kosuke Yoshida Satoshi Tamauchi Akira Yokoi Nobuhisa Yoshikawa Kaoru Niimi Hiroyuki Tomita Hiroyasu Kidoya Yukihiro Shiraki Atsushi Enomoto Hiroaki Kajiyama |
| author_facet | Emiri Miyamoto Masato Yoshihara Shohei Iyoshi Kazumasa Mogi Kaname Uno Hiroki Fujimoto Yoshihiro Koya Kazuhisa Kitami Kosuke Yoshida Satoshi Tamauchi Akira Yokoi Nobuhisa Yoshikawa Kaoru Niimi Hiroyuki Tomita Hiroyasu Kidoya Yukihiro Shiraki Atsushi Enomoto Hiroaki Kajiyama |
| author_sort | Emiri Miyamoto |
| collection | DOAJ |
| description | Abstract The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis, and neutrophil indicators from blood tests. Survival analysis showed that neutrophil infiltration in the primary tumor had no impact on prognosis, whereas high neutrophil infiltration in the disseminated tumor significantly shortened progression-free survival and overall survival. No correlation was found between neutrophil infiltration and the number of peripheral blood neutrophils, the degree of neutropenia, area of vascular endothelial cells, and number of stromal cells. Neutrophil infiltration into disseminated lesions of the omentum has a significant impact on prognosis. The results of the present study may provide insights for refining clinical approaches. |
| format | Article |
| id | doaj-art-8bb276388a9c42c489a68d34cc44ef01 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8bb276388a9c42c489a68d34cc44ef012025-08-20T04:01:34ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-05010-3Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancerEmiri Miyamoto0Masato Yoshihara1Shohei Iyoshi2Kazumasa Mogi3Kaname Uno4Hiroki Fujimoto5Yoshihiro Koya6Kazuhisa Kitami7Kosuke Yoshida8Satoshi Tamauchi9Akira Yokoi10Nobuhisa Yoshikawa11Kaoru Niimi12Hiroyuki Tomita13Hiroyasu Kidoya14Yukihiro Shiraki15Atsushi Enomoto16Hiroaki Kajiyama17Department of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Gynecologic Oncology, Aichi Cancer CenterDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Tumor Pathology, Graduate School of Medicine, Gifu UniversityDepartment of Integrative Vascular Biology, Faculty of Medical Sciences, University of FukuiDepartment of Pathology, Graduate School of Medicine, Nagoya UniversityDepartment of Pathology, Graduate School of Medicine, Nagoya UniversityDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineAbstract The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis, and neutrophil indicators from blood tests. Survival analysis showed that neutrophil infiltration in the primary tumor had no impact on prognosis, whereas high neutrophil infiltration in the disseminated tumor significantly shortened progression-free survival and overall survival. No correlation was found between neutrophil infiltration and the number of peripheral blood neutrophils, the degree of neutropenia, area of vascular endothelial cells, and number of stromal cells. Neutrophil infiltration into disseminated lesions of the omentum has a significant impact on prognosis. The results of the present study may provide insights for refining clinical approaches.https://doi.org/10.1038/s41598-025-05010-3Ovarian carcinomaNeutrophilPrognosisPeritoneal metastasis |
| spellingShingle | Emiri Miyamoto Masato Yoshihara Shohei Iyoshi Kazumasa Mogi Kaname Uno Hiroki Fujimoto Yoshihiro Koya Kazuhisa Kitami Kosuke Yoshida Satoshi Tamauchi Akira Yokoi Nobuhisa Yoshikawa Kaoru Niimi Hiroyuki Tomita Hiroyasu Kidoya Yukihiro Shiraki Atsushi Enomoto Hiroaki Kajiyama Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer Scientific Reports Ovarian carcinoma Neutrophil Prognosis Peritoneal metastasis |
| title | Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| title_full | Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| title_fullStr | Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| title_full_unstemmed | Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| title_short | Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| title_sort | neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer |
| topic | Ovarian carcinoma Neutrophil Prognosis Peritoneal metastasis |
| url | https://doi.org/10.1038/s41598-025-05010-3 |
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