p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway
Basal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years, proBDNF and its receptor p75NTR have been rep...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6652846 |
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| _version_ | 1850213109534294016 |
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| author | Qingli Lu Yuanyuan Qu Yuan Ding Xiaojing Kang |
| author_facet | Qingli Lu Yuanyuan Qu Yuan Ding Xiaojing Kang |
| author_sort | Qingli Lu |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years, proBDNF and its receptor p75NTR have been reported to play important roles in various diseases, including cancers and psychotic disorders. However, the role of p75NTR/proBDNF signaling in basal cell carcinoma remains unclear. Here, we found that the expression level of p75NTR/proBDNF was decreased in basal cell carcinoma patient samples and cell lines. In vitro study showed overexpression of p75NTR/proBDNF could significantly facilitate tumor cell death, including inflammatory-silent apoptosis and lytic inflammatory activated necroptosis. In vivo study showed overexpression of p75NTR/proBDNF dramatically promotes tumor-associated macrophage (M1) and T cell recruitment in a syngeneic mouse model of BCC. These results show a crucial role for p75NTR/proBDNF signaling in basal cell carcinoma immune microenvironment. |
| format | Article |
| id | doaj-art-8bb113b4ff7c4bb7aedb18f4b6f085d3 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8bb113b4ff7c4bb7aedb18f4b6f085d32025-08-20T02:09:11ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66528466652846p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling PathwayQingli Lu0Yuanyuan Qu1Yuan Ding2Xiaojing Kang3Department of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, ChinaDepartment of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, ChinaDepartment of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, ChinaDepartment of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, ChinaBasal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years, proBDNF and its receptor p75NTR have been reported to play important roles in various diseases, including cancers and psychotic disorders. However, the role of p75NTR/proBDNF signaling in basal cell carcinoma remains unclear. Here, we found that the expression level of p75NTR/proBDNF was decreased in basal cell carcinoma patient samples and cell lines. In vitro study showed overexpression of p75NTR/proBDNF could significantly facilitate tumor cell death, including inflammatory-silent apoptosis and lytic inflammatory activated necroptosis. In vivo study showed overexpression of p75NTR/proBDNF dramatically promotes tumor-associated macrophage (M1) and T cell recruitment in a syngeneic mouse model of BCC. These results show a crucial role for p75NTR/proBDNF signaling in basal cell carcinoma immune microenvironment.http://dx.doi.org/10.1155/2021/6652846 |
| spellingShingle | Qingli Lu Yuanyuan Qu Yuan Ding Xiaojing Kang p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway Journal of Immunology Research |
| title | p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway |
| title_full | p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway |
| title_fullStr | p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway |
| title_full_unstemmed | p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway |
| title_short | p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway |
| title_sort | p75ntr probdnf modulates basal cell carcinoma bcc immune microenvironment via necroptosis signaling pathway |
| url | http://dx.doi.org/10.1155/2021/6652846 |
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