A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation
Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425005873 |
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| author | Jianyu Qiu Xitong Kang Tao Liu Jing Liu Huansheng Liu Xiyang Zhao Yong Li Qi Liu Zhenzhen Nong Qingwen Wang Zhenzhen Liu |
| author_facet | Jianyu Qiu Xitong Kang Tao Liu Jing Liu Huansheng Liu Xiyang Zhao Yong Li Qi Liu Zhenzhen Nong Qingwen Wang Zhenzhen Liu |
| author_sort | Jianyu Qiu |
| collection | DOAJ |
| description | Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by one-step of directed freeze-casting technique via utilizing the FDA-approved poly (vinyl alcohol) (PVA) and carboxymethylcellulose nanofibril (CNF) as the network backbone without any chemical crosslinker. This fully physical crosslinked hydrogel exhibits remarkable mechanical performance because of the highly oriented microstructure and multiple hydrogen bonding, including the matching mechanical property with soft tissue, anti-tearing capability, the great 99 % retention of tensile stress and higher toughness after soaking at PBS for 7 days. And the extremely low swelling ratio of 5.9 % in PBS and combining the higher water-content is superior to other reported anti-swelling hydrogel. Importantly, besides as a robust physical barrier of this hydrogel patch, it also displays the excellent inflammatory regulation via capturing the positively charged proinflammatory cytokines because of the incorporation of the negatively charged CNF, synergistically promoting the remarkable anti-adhesion and tissue pro-healing efficiency. By integrating the anti-adhesion, tissue pro-healing, long-lasting anti-deformation in vivo and excellent bio-compatibility, this hydrogel provides a great candidate of anti-adhesion patch for tension-free repair operations. |
| format | Article |
| id | doaj-art-8bad9c721d7349e0abdcd561b0ffeacb |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-8bad9c721d7349e0abdcd561b0ffeacb2025-08-20T03:24:08ZengElsevierMaterials Today Bio2590-00642025-08-013310201710.1016/j.mtbio.2025.102017A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulationJianyu Qiu0Xitong Kang1Tao Liu2Jing Liu3Huansheng Liu4Xiyang Zhao5Yong Li6Qi Liu7Zhenzhen Nong8Qingwen Wang9Zhenzhen Liu10Institute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou, 510642, China; Corresponding author.Institute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou, 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou, 510642, ChinaInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, ChinaThe Third Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China; Institute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China; Corresponding author. The Third Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China.Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by one-step of directed freeze-casting technique via utilizing the FDA-approved poly (vinyl alcohol) (PVA) and carboxymethylcellulose nanofibril (CNF) as the network backbone without any chemical crosslinker. This fully physical crosslinked hydrogel exhibits remarkable mechanical performance because of the highly oriented microstructure and multiple hydrogen bonding, including the matching mechanical property with soft tissue, anti-tearing capability, the great 99 % retention of tensile stress and higher toughness after soaking at PBS for 7 days. And the extremely low swelling ratio of 5.9 % in PBS and combining the higher water-content is superior to other reported anti-swelling hydrogel. Importantly, besides as a robust physical barrier of this hydrogel patch, it also displays the excellent inflammatory regulation via capturing the positively charged proinflammatory cytokines because of the incorporation of the negatively charged CNF, synergistically promoting the remarkable anti-adhesion and tissue pro-healing efficiency. By integrating the anti-adhesion, tissue pro-healing, long-lasting anti-deformation in vivo and excellent bio-compatibility, this hydrogel provides a great candidate of anti-adhesion patch for tension-free repair operations.http://www.sciencedirect.com/science/article/pii/S2590006425005873Anti-adhesion hydrogelAnti-swellingPost-operative adhesionTissue pro-healingInflammatory regulation |
| spellingShingle | Jianyu Qiu Xitong Kang Tao Liu Jing Liu Huansheng Liu Xiyang Zhao Yong Li Qi Liu Zhenzhen Nong Qingwen Wang Zhenzhen Liu A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation Materials Today Bio Anti-adhesion hydrogel Anti-swelling Post-operative adhesion Tissue pro-healing Inflammatory regulation |
| title | A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation |
| title_full | A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation |
| title_fullStr | A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation |
| title_full_unstemmed | A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation |
| title_short | A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation |
| title_sort | non swellable anisotropic hydrogel patch with superior mechanical stability for internal anti adhesion via physical barrier and inflammation regulation |
| topic | Anti-adhesion hydrogel Anti-swelling Post-operative adhesion Tissue pro-healing Inflammatory regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425005873 |
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