Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke
Given that ischemic stroke ranks as one of the most fatal diseases globally, it is imperative to develop clinically effective neuroprotective agents for stroke. Microglia serve as innate immune cells for maintaining brain homeostasis, and upon activation, they are well-known to be able to transform...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1580479/full |
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| author | Lu Yu Yin Dong Mincheng Li Huifang Liu Cuina Yan Xiaoxian Li Yuehua Gu Liwei Wang Chuan Xu Jie Xu Zhen Yuan Ming Xia Jiwei Cheng |
| author_facet | Lu Yu Yin Dong Mincheng Li Huifang Liu Cuina Yan Xiaoxian Li Yuehua Gu Liwei Wang Chuan Xu Jie Xu Zhen Yuan Ming Xia Jiwei Cheng |
| author_sort | Lu Yu |
| collection | DOAJ |
| description | Given that ischemic stroke ranks as one of the most fatal diseases globally, it is imperative to develop clinically effective neuroprotective agents for stroke. Microglia serve as innate immune cells for maintaining brain homeostasis, and upon activation, they are well-known to be able to transform into two functional phenotypes, namely, the M1 and M2 types, which can convert each other and exert opposing effects on neurotoxicity and neuroprotection, respectively. Traditional Chinese medicine possesses a deep-rooted and profound history with rich theory in treating cerebrovascular disorders, and its natural compounds have been considered as promising adjunctive therapies. Recently, researchers have been devoting attention to the inflammation-suppressive properties of the compounds from Chinese herbs. These compounds are gradually emerging as adoptable therapeutic agents with wide application prospect for improving stroke outcomes, through regulating microglial polarization to attenuate neuroinflammation. Thereby, we reviewed the functions of microglial cells in inflammation and neuroprotection and explored the regulation of microglial activity by natural compounds to alleviate neuroinflammation and protect neural function after ischemic stroke. Collectively, using natural compounds to suppress the microglia-mediated detrimental inflammatory response, meanwhile enhancing their anti-inflammatory abilities to accelerate neuronal recovery, will be promising therapeutic approaches for ischemic stroke. |
| format | Article |
| id | doaj-art-8ba8b56daefe47cdbabbb19fa39b53ae |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-8ba8b56daefe47cdbabbb19fa39b53ae2025-08-20T02:08:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.15804791580479Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic strokeLu Yu0Yin Dong1Mincheng Li2Huifang Liu3Cuina Yan4Xiaoxian Li5Yuehua Gu6Liwei Wang7Chuan Xu8Jie Xu9Zhen Yuan10Ming Xia11Jiwei Cheng12Comprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai Jinshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Medicine, Xinqiao Community Health Service Center, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaComprehensive Department of Traditional Chinese Medicine, Department of Neurology, First Department of Integration, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaGiven that ischemic stroke ranks as one of the most fatal diseases globally, it is imperative to develop clinically effective neuroprotective agents for stroke. Microglia serve as innate immune cells for maintaining brain homeostasis, and upon activation, they are well-known to be able to transform into two functional phenotypes, namely, the M1 and M2 types, which can convert each other and exert opposing effects on neurotoxicity and neuroprotection, respectively. Traditional Chinese medicine possesses a deep-rooted and profound history with rich theory in treating cerebrovascular disorders, and its natural compounds have been considered as promising adjunctive therapies. Recently, researchers have been devoting attention to the inflammation-suppressive properties of the compounds from Chinese herbs. These compounds are gradually emerging as adoptable therapeutic agents with wide application prospect for improving stroke outcomes, through regulating microglial polarization to attenuate neuroinflammation. Thereby, we reviewed the functions of microglial cells in inflammation and neuroprotection and explored the regulation of microglial activity by natural compounds to alleviate neuroinflammation and protect neural function after ischemic stroke. Collectively, using natural compounds to suppress the microglia-mediated detrimental inflammatory response, meanwhile enhancing their anti-inflammatory abilities to accelerate neuronal recovery, will be promising therapeutic approaches for ischemic stroke.https://www.frontiersin.org/articles/10.3389/fcell.2025.1580479/fullischemic strokemicroglianeuroinflammationtraditional Chinese herbsnatural compounds |
| spellingShingle | Lu Yu Yin Dong Mincheng Li Huifang Liu Cuina Yan Xiaoxian Li Yuehua Gu Liwei Wang Chuan Xu Jie Xu Zhen Yuan Ming Xia Jiwei Cheng Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke Frontiers in Cell and Developmental Biology ischemic stroke microglia neuroinflammation traditional Chinese herbs natural compounds |
| title | Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke |
| title_full | Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke |
| title_fullStr | Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke |
| title_full_unstemmed | Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke |
| title_short | Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke |
| title_sort | targeting microglia polarization with chinese herb derived natural compounds for neuroprotection in ischemic stroke |
| topic | ischemic stroke microglia neuroinflammation traditional Chinese herbs natural compounds |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1580479/full |
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