Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals
Abstract This study investigated effects of experimental baroreceptor stimulation on bilateral blood flow velocities in the anterior and middle cerebral arteries (ACA and MCA) using functional transcranial Doppler sonography. Carotid baroreceptors were stimulated by neck suction in 33 healthy partic...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Physiological Sciences |
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| Online Access: | https://doi.org/10.1186/s12576-023-00871-7 |
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| author | Gustavo A. Reyes del Paso Casandra I. Montoro J. Richard Jennings Stefan Duschek |
| author_facet | Gustavo A. Reyes del Paso Casandra I. Montoro J. Richard Jennings Stefan Duschek |
| author_sort | Gustavo A. Reyes del Paso |
| collection | DOAJ |
| description | Abstract This study investigated effects of experimental baroreceptor stimulation on bilateral blood flow velocities in the anterior and middle cerebral arteries (ACA and MCA) using functional transcranial Doppler sonography. Carotid baroreceptors were stimulated by neck suction in 33 healthy participants. Therefore, negative pressure (− 50 mmHg) was applied; neck pressure (+ 10 mmHg) was used as a control condition. Heart rate (HR) and blood pressure (BP) were also continuously recorded. Neck suction led to reductions in bilateral ACA and MCA blood flow velocities, which accompanied the expected HR and BP decreases; HR and BP decreases correlated positively with the ACA flow velocity decline. The observations suggest reduction of blood flow in the perfusion territories of the ACA and MCA during baroreceptor stimulation. Baroreceptor-related HR and BP decreases may contribute to the cerebral blood flow decline. The findings underline the interaction between peripheral and cerebral hemodynamic regulation in autoregulatory control of cerebral perfusion. |
| format | Article |
| id | doaj-art-8ba4ce5ce27443a89f360bde7f87807a |
| institution | Kabale University |
| issn | 1880-6562 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-8ba4ce5ce27443a89f360bde7f87807a2025-08-20T03:37:41ZengElsevierJournal of Physiological Sciences1880-65622023-06-017311910.1186/s12576-023-00871-7Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individualsGustavo A. Reyes del Paso0Casandra I. Montoro1J. Richard Jennings2Stefan Duschek3Department of Psychology, University of JaénDepartment of Psychology, University of JaénDepartment of Psychiatry, School of Medicine, University of PittsburghUMIT TIROL - University for Health Sciences and TechnologyAbstract This study investigated effects of experimental baroreceptor stimulation on bilateral blood flow velocities in the anterior and middle cerebral arteries (ACA and MCA) using functional transcranial Doppler sonography. Carotid baroreceptors were stimulated by neck suction in 33 healthy participants. Therefore, negative pressure (− 50 mmHg) was applied; neck pressure (+ 10 mmHg) was used as a control condition. Heart rate (HR) and blood pressure (BP) were also continuously recorded. Neck suction led to reductions in bilateral ACA and MCA blood flow velocities, which accompanied the expected HR and BP decreases; HR and BP decreases correlated positively with the ACA flow velocity decline. The observations suggest reduction of blood flow in the perfusion territories of the ACA and MCA during baroreceptor stimulation. Baroreceptor-related HR and BP decreases may contribute to the cerebral blood flow decline. The findings underline the interaction between peripheral and cerebral hemodynamic regulation in autoregulatory control of cerebral perfusion.https://doi.org/10.1186/s12576-023-00871-7BaroreceptorBlood pressureHeart rateCerebral blood flowTranscranial Doppler sonography |
| spellingShingle | Gustavo A. Reyes del Paso Casandra I. Montoro J. Richard Jennings Stefan Duschek Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals Journal of Physiological Sciences Baroreceptor Blood pressure Heart rate Cerebral blood flow Transcranial Doppler sonography |
| title | Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| title_full | Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| title_fullStr | Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| title_full_unstemmed | Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| title_short | Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| title_sort | experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals |
| topic | Baroreceptor Blood pressure Heart rate Cerebral blood flow Transcranial Doppler sonography |
| url | https://doi.org/10.1186/s12576-023-00871-7 |
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