Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review
Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechani...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Japanese Dental Science Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S188276162500016X |
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| author | Alfredo Torres Leonardo Díaz Jaime Oyarzún M. Angélica Michea Xiaowei Xu Flavio Salazar-Onfray Fermín E. González |
| author_facet | Alfredo Torres Leonardo Díaz Jaime Oyarzún M. Angélica Michea Xiaowei Xu Flavio Salazar-Onfray Fermín E. González |
| author_sort | Alfredo Torres |
| collection | DOAJ |
| description | Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechanisms in the progression of periodontitis. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science and Scopus, complemented by manual searching in Google Scholar, following PRISMA guidelines. After removing duplicates, 549 studies underwent title and abstract screening. Of these, 56 articles were selected for full-text review and 18 studies met the eligibility criteria and were included in the final synthesis. Ferroptosis, pyroptosis and necroptosis were consistently associated with inflammatory exacerbation, alveolar bone loss and disease progression. In contrast, autophagy and apoptosis exhibited dual roles—protective or destructive—depending on cell types, disease stage and experimental conditions. Most studies utilized ligature-induced periodontitis animal models. Several studies also demonstrated the therapeutic potential of modulating specific RCD pathways to control inflammation and promote periodontal tissue regeneration, highlighting possible translational strategies for host-modulation therapy of periodontitis. This systematic review consolidates the pivotal role of RCD in the progression of periodontitis. Targeting RCD pathways may represent novel therapeutic strategies to reduce periodontal inflammation and tissue destruction. |
| format | Article |
| id | doaj-art-8ba1d9b862ef43f2a46809925101c5b2 |
| institution | Kabale University |
| issn | 1882-7616 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj-art-8ba1d9b862ef43f2a46809925101c5b22025-08-24T05:12:01ZengElsevierJapanese Dental Science Review1882-76162025-12-016121322610.1016/j.jdsr.2025.08.001Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic reviewAlfredo Torres0Leonardo Díaz1Jaime Oyarzún2M. Angélica Michea3Xiaowei Xu4Flavio Salazar-Onfray5Fermín E. González6Laboratory of Experimental Immunology & Cancer, Faculty of Dentistry, University of Chile, Santiago, Chile; Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, ChileDepartment of Prosthodontics, Faculty of Dentistry, University of Chile, Santiago, Chile; Department of Stomatology, Faculty of Dentistry, Universidad de Sevilla, Sevilla, Spain; Perioplastic Institute, Santiago, ChileLaboratory of Experimental Immunology & Cancer, Faculty of Dentistry, University of Chile, Santiago, ChileDepartment of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, ChileDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, PR ChinaInstitute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; Millennium Institute for Immunology and Immunotherapy, Faculty of Medicine, University of Chile, Santiago, ChileLaboratory of Experimental Immunology & Cancer, Faculty of Dentistry, University of Chile, Santiago, Chile; Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, Chile; Correspondence to: Laboratory of Experimental Immunology & Cancer, Faculty of Dentistry, University of Chile, Olivos 943, Independencia, Santiago 8380492, Chile.Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechanisms in the progression of periodontitis. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science and Scopus, complemented by manual searching in Google Scholar, following PRISMA guidelines. After removing duplicates, 549 studies underwent title and abstract screening. Of these, 56 articles were selected for full-text review and 18 studies met the eligibility criteria and were included in the final synthesis. Ferroptosis, pyroptosis and necroptosis were consistently associated with inflammatory exacerbation, alveolar bone loss and disease progression. In contrast, autophagy and apoptosis exhibited dual roles—protective or destructive—depending on cell types, disease stage and experimental conditions. Most studies utilized ligature-induced periodontitis animal models. Several studies also demonstrated the therapeutic potential of modulating specific RCD pathways to control inflammation and promote periodontal tissue regeneration, highlighting possible translational strategies for host-modulation therapy of periodontitis. This systematic review consolidates the pivotal role of RCD in the progression of periodontitis. Targeting RCD pathways may represent novel therapeutic strategies to reduce periodontal inflammation and tissue destruction.http://www.sciencedirect.com/science/article/pii/S188276162500016XPeriodontitisRegulated cell deathDisease progression |
| spellingShingle | Alfredo Torres Leonardo Díaz Jaime Oyarzún M. Angélica Michea Xiaowei Xu Flavio Salazar-Onfray Fermín E. González Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review Japanese Dental Science Review Periodontitis Regulated cell death Disease progression |
| title | Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review |
| title_full | Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review |
| title_fullStr | Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review |
| title_full_unstemmed | Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review |
| title_short | Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review |
| title_sort | interplay between survival and regulated cell death mechanisms during periodontitis progression a systematic review |
| topic | Periodontitis Regulated cell death Disease progression |
| url | http://www.sciencedirect.com/science/article/pii/S188276162500016X |
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