Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial
Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. Although catheter ablation is the most efficacious therapy, relapses occur frequently (30%) in the first year after ablation. Novel biomarkers of recurrence are needed for a better prediction...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-01-01
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| Series: | Lifestyle Genomics |
| Online Access: | https://karger.com/article/doi/10.1159/000543639 |
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| author | Cristina Razquin Joaquín Fernandez-Irigoyen María Teresa Barrio-López Begoña López Susana Ravassa Pablo Ramos Rosa Macías-Ruíz Alicia Ibañez Criado Enrique Santamaría Leticia Goni Eduardo Castellanos Jose Luis Ibañez Criado Luis Tercedor Ignacio García-Bolao Miguel A. Martínez-González Jesús Almendral Miguel Ruiz-Canela |
| author_facet | Cristina Razquin Joaquín Fernandez-Irigoyen María Teresa Barrio-López Begoña López Susana Ravassa Pablo Ramos Rosa Macías-Ruíz Alicia Ibañez Criado Enrique Santamaría Leticia Goni Eduardo Castellanos Jose Luis Ibañez Criado Luis Tercedor Ignacio García-Bolao Miguel A. Martínez-González Jesús Almendral Miguel Ruiz-Canela |
| author_sort | Cristina Razquin |
| collection | DOAJ |
| description |
Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. Although catheter ablation is the most efficacious therapy, relapses occur frequently (30%) in the first year after ablation. Novel biomarkers of recurrence are needed for a better prediction of recurrence and management of AF. In this pilot study, we aimed to analyze the baseline proteome of subjects included in a case-control study to find differential proteins associated with AF recurrence. Methods: Baseline serum proteomics (354 proteins) data from 16 cases (recurrent AF) and 17 controls (non-recurrent) were obtained using MS/MS analysis. A false discovery rate was performed using a nonlinear fitting method for the selection of proteins. Logistic regression models were used to further analyze the association between differentially expressed proteins and AF recurrence. Results: Ten proteins were differentially represented in cases vs. controls. Two were upregulated in the cases compared to the controls: keratin type I cytoskeletal 17 (Fold-change [FC] = 2.14; p = 0.017) and endoplasmic bifunctional protein (FC = 1.65; p = 0.032). Eight were downregulated in the cases compared to the controls: C4bpA (FC = 0.64; p = 0.006), coagulation factor XI (FC = 0.83; p = 0.011), CLIC1 (FC = 0.62; p = 0.017), haptoglobin (FC = 0.37; p = 0.021), Ig alpha-2 chain C region (FC = 0.49; p = 0.022), C4bpB (FC = 0.73; p = 0.028), N-acetylglucosamine-1-phosphotransferase subunit gamma (FC = 0.61; p = 0.033), and platelet glycoprotein Ib alpha chain (FC = 0.84; p = 0.038). Conclusion: This pilot study identifies ten differentially expressed serum proteins associated with AF recurrence, offering potential biomarkers for improved prediction and management. |
| format | Article |
| id | doaj-art-8b9eaa5e71024a2abaf6543c912e9497 |
| institution | DOAJ |
| issn | 2504-3188 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
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| series | Lifestyle Genomics |
| spelling | doaj-art-8b9eaa5e71024a2abaf6543c912e94972025-08-20T03:09:48ZengKarger PublishersLifestyle Genomics2504-31882025-01-01181525810.1159/000543639Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR TrialCristina RazquinJoaquín Fernandez-IrigoyenMaría Teresa Barrio-LópezBegoña LópezSusana RavassaPablo RamosRosa Macías-RuízAlicia Ibañez CriadoEnrique SantamaríaLeticia GoniEduardo CastellanosJose Luis Ibañez CriadoLuis TercedorIgnacio García-BolaoMiguel A. Martínez-GonzálezJesús AlmendralMiguel Ruiz-Canela Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. Although catheter ablation is the most efficacious therapy, relapses occur frequently (30%) in the first year after ablation. Novel biomarkers of recurrence are needed for a better prediction of recurrence and management of AF. In this pilot study, we aimed to analyze the baseline proteome of subjects included in a case-control study to find differential proteins associated with AF recurrence. Methods: Baseline serum proteomics (354 proteins) data from 16 cases (recurrent AF) and 17 controls (non-recurrent) were obtained using MS/MS analysis. A false discovery rate was performed using a nonlinear fitting method for the selection of proteins. Logistic regression models were used to further analyze the association between differentially expressed proteins and AF recurrence. Results: Ten proteins were differentially represented in cases vs. controls. Two were upregulated in the cases compared to the controls: keratin type I cytoskeletal 17 (Fold-change [FC] = 2.14; p = 0.017) and endoplasmic bifunctional protein (FC = 1.65; p = 0.032). Eight were downregulated in the cases compared to the controls: C4bpA (FC = 0.64; p = 0.006), coagulation factor XI (FC = 0.83; p = 0.011), CLIC1 (FC = 0.62; p = 0.017), haptoglobin (FC = 0.37; p = 0.021), Ig alpha-2 chain C region (FC = 0.49; p = 0.022), C4bpB (FC = 0.73; p = 0.028), N-acetylglucosamine-1-phosphotransferase subunit gamma (FC = 0.61; p = 0.033), and platelet glycoprotein Ib alpha chain (FC = 0.84; p = 0.038). Conclusion: This pilot study identifies ten differentially expressed serum proteins associated with AF recurrence, offering potential biomarkers for improved prediction and management. https://karger.com/article/doi/10.1159/000543639 |
| spellingShingle | Cristina Razquin Joaquín Fernandez-Irigoyen María Teresa Barrio-López Begoña López Susana Ravassa Pablo Ramos Rosa Macías-Ruíz Alicia Ibañez Criado Enrique Santamaría Leticia Goni Eduardo Castellanos Jose Luis Ibañez Criado Luis Tercedor Ignacio García-Bolao Miguel A. Martínez-González Jesús Almendral Miguel Ruiz-Canela Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial Lifestyle Genomics |
| title | Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial |
| title_full | Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial |
| title_fullStr | Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial |
| title_full_unstemmed | Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial |
| title_short | Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial |
| title_sort | proteomics and recurrence of atrial fibrillation a pilot study nested in the predimar trial |
| url | https://karger.com/article/doi/10.1159/000543639 |
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