GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?
Due to unfavorable lifestyle habits (unhealthy diet and tobacco abuse) the incidence of gastroesophageal reflux disease (GERD) in western countries is increasing. The GERD-Barrett-Adenocarcinoma sequence currently lacks well-defined diagnostic, progressive, predictive, and prognostic biomarkers (i)...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/643084 |
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| _version_ | 1832566220910493696 |
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| author | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter |
| author_facet | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter |
| author_sort | Romana Illig |
| collection | DOAJ |
| description | Due to unfavorable lifestyle habits (unhealthy diet and tobacco abuse) the incidence of gastroesophageal reflux disease (GERD) in western countries is increasing. The GERD-Barrett-Adenocarcinoma sequence currently lacks well-defined diagnostic, progressive, predictive, and prognostic biomarkers (i) providing an appropriate screening method identifying the presence of the disease, (ii) estimating the risk of evolving cancer, that is, the progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC), (iii) predicting the response to therapy, and (iv) indicating an overall survival—prognosis for EAC patients. Based on histomorphological findings, detailed screening and therapeutic guidelines have been elaborated, although epidemiological studies could not support the postulated increasing progression rates of GERD to BE and EAC. Additionally, proposed predictive and prognostic markers are rather heterogeneous by nature, lack substantial proofs, and currently do not allow stratification of GERD patients for progression, outcome, and therapeutic effectiveness in clinical practice. The aim of this paper is to discuss the current knowledge regarding the GERD-BE-EAC sequence mainly focusing on the disputable and ambiguous status of proposed biomarkers to identify promising and reliable markers in order to provide more detailed insights into pathophysiological mechanisms and thus to improve prognostic and predictive therapeutic approaches. |
| format | Article |
| id | doaj-art-8b9aa3d9fe7c4978bc34485b6b7054d7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8b9aa3d9fe7c4978bc34485b6b7054d72025-02-03T01:04:49ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/643084643084GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?Romana Illig0Eckhard Klieser1Tobias Kiesslich2Daniel Neureiter3Institute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner HauptstraBe 48, 5020 Salzburg, AustriaInstitute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner HauptstraBe 48, 5020 Salzburg, AustriaInstitute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner HauptstraBe 48, 5020 Salzburg, AustriaInstitute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner HauptstraBe 48, 5020 Salzburg, AustriaDue to unfavorable lifestyle habits (unhealthy diet and tobacco abuse) the incidence of gastroesophageal reflux disease (GERD) in western countries is increasing. The GERD-Barrett-Adenocarcinoma sequence currently lacks well-defined diagnostic, progressive, predictive, and prognostic biomarkers (i) providing an appropriate screening method identifying the presence of the disease, (ii) estimating the risk of evolving cancer, that is, the progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC), (iii) predicting the response to therapy, and (iv) indicating an overall survival—prognosis for EAC patients. Based on histomorphological findings, detailed screening and therapeutic guidelines have been elaborated, although epidemiological studies could not support the postulated increasing progression rates of GERD to BE and EAC. Additionally, proposed predictive and prognostic markers are rather heterogeneous by nature, lack substantial proofs, and currently do not allow stratification of GERD patients for progression, outcome, and therapeutic effectiveness in clinical practice. The aim of this paper is to discuss the current knowledge regarding the GERD-BE-EAC sequence mainly focusing on the disputable and ambiguous status of proposed biomarkers to identify promising and reliable markers in order to provide more detailed insights into pathophysiological mechanisms and thus to improve prognostic and predictive therapeutic approaches.http://dx.doi.org/10.1155/2013/643084 |
| spellingShingle | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? Gastroenterology Research and Practice |
| title | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? |
| title_full | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? |
| title_fullStr | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? |
| title_full_unstemmed | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? |
| title_short | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? |
| title_sort | gerd barrett adenocarcinoma do we have suitable prognostic and predictive molecular markers |
| url | http://dx.doi.org/10.1155/2013/643084 |
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