Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database
Background. The objective of this study is to determine the prognostic factors of keratinizing squamous cell carcinoma of the tongue (KTSCC) and to establish a prognostic nomogram of KTSCC to assist clinical diagnosis and treatment. Methods. This study identified 3874 patients with KTSCC from the Su...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/3016994 |
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| author | Hai Yu Shuping Xie Xinkai Zheng Qiqi Zhao Xichun Xia Wai-Kit Ming Leong Nga Cheng Xi Duan WenHsien Ethan Huang Fang Huang Jun Lyu Liehua Deng |
| author_facet | Hai Yu Shuping Xie Xinkai Zheng Qiqi Zhao Xichun Xia Wai-Kit Ming Leong Nga Cheng Xi Duan WenHsien Ethan Huang Fang Huang Jun Lyu Liehua Deng |
| author_sort | Hai Yu |
| collection | DOAJ |
| description | Background. The objective of this study is to determine the prognostic factors of keratinizing squamous cell carcinoma of the tongue (KTSCC) and to establish a prognostic nomogram of KTSCC to assist clinical diagnosis and treatment. Methods. This study identified 3874 patients with KTSCC from the Surveillance, Epidemiology, and End Results (SEER) database, and these patients were randomly divided into the training (70%, (n = 2711) and validation (30%, n = 1163) cohorts. Cox regression was then used to filter variables. Nomograms were then constructed based on meaningful variables. Finally, the concordance index (C-index), net reclassification index (NRI), integrated discrimination improvement (IDI), calibration charts, and decision-curve analysis (DCA), were used to evaluate the discrimination, accuracy and effectiveness of the model. Results. A nomogram model was established for predicting the 3-, 5-, and 8-year overall survival (OS) probabilities of patients with KTSCC. The model indicated that age, radiotherapy sequence, SEER stage, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, radiotherapy status, race, lymph node dissection status, and sex were factors influencing the OS of patients with KTSCC. Verified by C-index, NRI, IDI, calibration curve, and DCA curve, our model has better discrimination, calibration, accuracy and net benefit compared to the AJCC system. Conclusions. This study identified the factors that affect the survival of KTSCC patients and established a prognostic nomogram that can help clinicians predict the 3-, 5-, and 8-year survival rates of KTSCC patients. |
| format | Article |
| id | doaj-art-8b961ead0a5f40879fb859efed3faf09 |
| institution | Kabale University |
| issn | 1742-1241 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-8b961ead0a5f40879fb859efed3faf092025-02-03T06:42:39ZengWileyInternational Journal of Clinical Practice1742-12412023-01-01202310.1155/2023/3016994Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results DatabaseHai Yu0Shuping Xie1Xinkai Zheng2Qiqi Zhao3Xichun Xia4Wai-Kit Ming5Leong Nga Cheng6Xi Duan7WenHsien Ethan Huang8Fang Huang9Jun Lyu10Liehua Deng11Department of DermatologySchool of Basic Medicine and Public HealthDepartment of DermatologyDepartment of DermatologyInstitute of Biomedical TransformationDepartment of Infectious Diseases and Public HealthDepartment of DermatologyDepartment of DermatologyGene Hope ClinicDepartment of DermatologyDepartment of Clinical ResearchDepartment of DermatologyBackground. The objective of this study is to determine the prognostic factors of keratinizing squamous cell carcinoma of the tongue (KTSCC) and to establish a prognostic nomogram of KTSCC to assist clinical diagnosis and treatment. Methods. This study identified 3874 patients with KTSCC from the Surveillance, Epidemiology, and End Results (SEER) database, and these patients were randomly divided into the training (70%, (n = 2711) and validation (30%, n = 1163) cohorts. Cox regression was then used to filter variables. Nomograms were then constructed based on meaningful variables. Finally, the concordance index (C-index), net reclassification index (NRI), integrated discrimination improvement (IDI), calibration charts, and decision-curve analysis (DCA), were used to evaluate the discrimination, accuracy and effectiveness of the model. Results. A nomogram model was established for predicting the 3-, 5-, and 8-year overall survival (OS) probabilities of patients with KTSCC. The model indicated that age, radiotherapy sequence, SEER stage, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, radiotherapy status, race, lymph node dissection status, and sex were factors influencing the OS of patients with KTSCC. Verified by C-index, NRI, IDI, calibration curve, and DCA curve, our model has better discrimination, calibration, accuracy and net benefit compared to the AJCC system. Conclusions. This study identified the factors that affect the survival of KTSCC patients and established a prognostic nomogram that can help clinicians predict the 3-, 5-, and 8-year survival rates of KTSCC patients.http://dx.doi.org/10.1155/2023/3016994 |
| spellingShingle | Hai Yu Shuping Xie Xinkai Zheng Qiqi Zhao Xichun Xia Wai-Kit Ming Leong Nga Cheng Xi Duan WenHsien Ethan Huang Fang Huang Jun Lyu Liehua Deng Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database International Journal of Clinical Practice |
| title | Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database |
| title_full | Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database |
| title_fullStr | Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database |
| title_full_unstemmed | Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database |
| title_short | Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database |
| title_sort | prognosis of the keratinizing squamous cell carcinoma of the tongue based on surveillance epidemiology and end results database |
| url | http://dx.doi.org/10.1155/2023/3016994 |
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