Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer
Abstract Background The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short‐ and l...
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| Language: | English |
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Wiley
2025-05-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12916 |
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| author | Takayuki Aiba Tomonori Akagi Hidefumi Shiroshita Kentaro Nakajima Tetsuji Ohyama Tatsuya Kinjo Akiyoshi Kanazawa Nobuaki Suzuki Takuya Tokunaga Manabu Yamamoto Nobuki Ichikawa Shungo Endo Yutaka Kojima Takatoshi Nakamura Shuji Saito Yoshinori Kagawa Shinobu Ohnuma Seiichiro Yamamoto Takeshi Naitoh Masafumi Inomata |
| author_facet | Takayuki Aiba Tomonori Akagi Hidefumi Shiroshita Kentaro Nakajima Tetsuji Ohyama Tatsuya Kinjo Akiyoshi Kanazawa Nobuaki Suzuki Takuya Tokunaga Manabu Yamamoto Nobuki Ichikawa Shungo Endo Yutaka Kojima Takatoshi Nakamura Shuji Saito Yoshinori Kagawa Shinobu Ohnuma Seiichiro Yamamoto Takeshi Naitoh Masafumi Inomata |
| author_sort | Takayuki Aiba |
| collection | DOAJ |
| description | Abstract Background The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short‐ and long‐term outcomes of laparoscopic surgery for obese colon cancer patients. Methods Obese (BMI ≥25 kg/m2) patients who underwent laparoscopic radical surgery for Stage II/III colon cancer at 46 participating centers from 2009 to 2013 were included. Associations between short‐ and long‐term outcomes and BMI as a continuous variable were analyzed by univariate and multivariate regression models. Results Among patients meeting the study criteria, 1036 were examined. BMI as a continuous variable correlated with log‐transformed operative time (regression coefficient: 0.02, 95% confidence interval [CI]: 0.012–0.028, p < 0.05) and blood loss (odds ratio: 1.089, 95% CI: 1.032–1.149, p < 0.05). There was no association between BMI continuous variables and 3‐year relapse‐free survival (RFS) and overall survival. However, 3‐year RFS was possibly better in patients with BMI ≥28.5 kg/m2 versus those with BMI <28.5 kg/m2 (hazard ratio: 0.682, 95% CI: 0.462–1.008, p = 0.055). Conclusions This study showed that BMI as a continuous variable correlated with operative time and blood loss. RFS was possibly better in the severely obese patients (BMI ≥28.5 kg/m2), suggesting that the prognosis for highly obese colon cancer patients appears to follow the obesity paradox. |
| format | Article |
| id | doaj-art-8b94e1c4b3de4ec2b4530973b18d7304 |
| institution | Kabale University |
| issn | 2475-0328 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj-art-8b94e1c4b3de4ec2b4530973b18d73042025-08-20T03:49:40ZengWileyAnnals of Gastroenterological Surgery2475-03282025-05-019339240010.1002/ags3.12916Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancerTakayuki Aiba0Tomonori Akagi1Hidefumi Shiroshita2Kentaro Nakajima3Tetsuji Ohyama4Tatsuya Kinjo5Akiyoshi Kanazawa6Nobuaki Suzuki7Takuya Tokunaga8Manabu Yamamoto9Nobuki Ichikawa10Shungo Endo11Yutaka Kojima12Takatoshi Nakamura13Shuji Saito14Yoshinori Kagawa15Shinobu Ohnuma16Seiichiro Yamamoto17Takeshi Naitoh18Masafumi Inomata19Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Yufu JapanDepartment of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Yufu JapanDepartment of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Yufu JapanDepartment of Surgery NTT Medical Center Tokyo Shinagawa‐ku JapanBiostatistics Center Kurume University Fukuoka JapanDepartment of Digestive and General Surgery University of the Ryukyus Hospital Nishihara JapanDepartment of Surgery Shimane Prefectural Central Hospital Izumo JapanDepartment of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube JapanDepartment of Digestive and Transplant Surgery Tokushima University Hospital Tokushima JapanDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery Tottori University Faculty of Medicine Yonago JapanDepartment of Gastroenterological Surgery I Graduate School of Medicine, Hokkaido University Sapporo JapanDepartment of Coloproctology Aizu Medical Center Fukushima Medical University Fukushima JapanDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Bunkyo‐ku JapanDepartment of Colorectal Surgery Dokkyo Medical University Shimotsuga‐gun JapanDivision of Surgery, Gastrointestinal Center Yokohama Shin‐Midori General Hospital Yokohama JapanDepartment of Gastroenterological Surgery Osaka International Cancer Institute Osaka JapanDepartment of Surgery Tohoku University Graduate School of Medicine Sendai JapanDepartment of Gastroenterological Surgery Tokai University School of Medicine Shibuya JapanDepartment of Lower Gastrointestinal Surgery Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Yufu JapanAbstract Background The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short‐ and long‐term outcomes of laparoscopic surgery for obese colon cancer patients. Methods Obese (BMI ≥25 kg/m2) patients who underwent laparoscopic radical surgery for Stage II/III colon cancer at 46 participating centers from 2009 to 2013 were included. Associations between short‐ and long‐term outcomes and BMI as a continuous variable were analyzed by univariate and multivariate regression models. Results Among patients meeting the study criteria, 1036 were examined. BMI as a continuous variable correlated with log‐transformed operative time (regression coefficient: 0.02, 95% confidence interval [CI]: 0.012–0.028, p < 0.05) and blood loss (odds ratio: 1.089, 95% CI: 1.032–1.149, p < 0.05). There was no association between BMI continuous variables and 3‐year relapse‐free survival (RFS) and overall survival. However, 3‐year RFS was possibly better in patients with BMI ≥28.5 kg/m2 versus those with BMI <28.5 kg/m2 (hazard ratio: 0.682, 95% CI: 0.462–1.008, p = 0.055). Conclusions This study showed that BMI as a continuous variable correlated with operative time and blood loss. RFS was possibly better in the severely obese patients (BMI ≥28.5 kg/m2), suggesting that the prognosis for highly obese colon cancer patients appears to follow the obesity paradox.https://doi.org/10.1002/ags3.12916body mass indexcolon cancercontinuous variablelaparoscopic surgeryobesity paradox |
| spellingShingle | Takayuki Aiba Tomonori Akagi Hidefumi Shiroshita Kentaro Nakajima Tetsuji Ohyama Tatsuya Kinjo Akiyoshi Kanazawa Nobuaki Suzuki Takuya Tokunaga Manabu Yamamoto Nobuki Ichikawa Shungo Endo Yutaka Kojima Takatoshi Nakamura Shuji Saito Yoshinori Kagawa Shinobu Ohnuma Seiichiro Yamamoto Takeshi Naitoh Masafumi Inomata Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer Annals of Gastroenterological Surgery body mass index colon cancer continuous variable laparoscopic surgery obesity paradox |
| title | Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| title_full | Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| title_fullStr | Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| title_full_unstemmed | Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| title_short | Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| title_sort | impact of body mass index as a continuous variable on short and long term outcomes in patients undergoing laparoscopic surgery for colon cancer |
| topic | body mass index colon cancer continuous variable laparoscopic surgery obesity paradox |
| url | https://doi.org/10.1002/ags3.12916 |
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