Epicardial Adipose Tissue: A Multimodal Imaging Diagnostic Perspective

Epicardial Adipose Tissue: A Multimodal Imaging Diagnostic Perspective

Epicardial adipose tissue (EAT), strategically located between the myocardium and the visceral pericardial layer, is increasingly recognized as an active player in cardiovascular health rather than a passive fat depot. EAT secretes a notable array of bioactive molecules known as adipokines, which ex...

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Main Authors: Giancarlo Trimarchi, Maria Ludovica Carerj, Concetta Zito, Gianluca Di Bella, Giovanni Taverna, Maurizio Cusmà Piccione, Pasquale Crea, Stefania Lo Giudice, Angela Buonpane, Michela Bonanni, Davide Restelli, Umberto Paradossi, Angelo Monteleone, Antonio Micari, Scipione Carerj
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Medicina
Subjects:
epicardial adipose tissue
multimodality imaging
pericoronary adipose tissue
echocardiography
Online Access:https://www.mdpi.com/1648-9144/61/6/961
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Summary:Epicardial adipose tissue (EAT), strategically located between the myocardium and the visceral pericardial layer, is increasingly recognized as an active player in cardiovascular health rather than a passive fat depot. EAT secretes a notable array of bioactive molecules known as adipokines, which exert critical exocrine and paracrine effects. Recent research has focused on pericoronary adipose tissue (PCAT)—the EAT surrounding coronary arteries—demonstrating its intricate bidirectional relationship with the vascular wall. Under normal physiological conditions, this interaction promotes vascular homeostasis; however, dysfunctional PCAT can release pro-inflammatory adipokines implicated in the pathogenesis of atherogenesis. Notably, PCAT inflammation has emerged as a significant factor associated with the development of coronary artery disease (CAD) and major cardiovascular events. This review seeks to elucidate the imaging methodologies employed to evaluate EAT, emphasizing cardiac computed tomography (CCT) as the preeminent imaging modality. Unlike echocardiography and cardiac magnetic resonance imaging, CCT not only visualizes and quantifies EAT but also concurrently assesses coronary arteries and PCAT. Recent findings have established the potential of CCT-derived PCAT attenuation as a noninvasive biomarker for coronary inflammation, offering prospects for monitoring therapeutic responses to innovative anti-inflammatory interventions in CAD management.
ISSN:1010-660X
1648-9144

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