PRL2 negatively regulates FcεRI mediated activation of mast cells

PRL2 negatively regulates FcεRI mediated activation of mast cells

Abstract Mast cells play a central role in allergic reactions, acting as key effector cells that initiate and amplify the inflammatory response. In this study, we demonstrate that phosphatase of regenerating liver 2 (PRL2) functions as a negative regulator of FcεRI-mediated mast cell activation. In...

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Main Authors: Xin Guo, Yunxuan Lei, Yanhua Xu, Xinyue Du, Lin Lin, Yanping Luo, Yebin Xi, Yinshi Guo, Xiaoyin Niu, Zhaojun Wang, Guangjie Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07649-2
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