Cognitive profile in mild cognitive impairment with Lewy bodies
Introduction: This study aimed to elucidate the cognitive profile of patients with mild cognitive impairment with Lewy bodies (MCI-LB) and to compare it to that of patients with mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Methods: Subjects older than 60 years with probable MCI-LB...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2023-08-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.11622/smedj.2022085 |
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| _version_ | 1823861416502755328 |
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| author | Shuai Liu Chunyan Liu Xiao-Dan Wang Huiru Lu Yong Ji |
| author_facet | Shuai Liu Chunyan Liu Xiao-Dan Wang Huiru Lu Yong Ji |
| author_sort | Shuai Liu |
| collection | DOAJ |
| description | Introduction:
This study aimed to elucidate the cognitive profile of patients with mild cognitive impairment with Lewy bodies (MCI-LB) and to compare it to that of patients with mild cognitive impairment due to Alzheimer’s disease (MCI-AD).
Methods:
Subjects older than 60 years with probable MCI-LB (n = 60) or MCI-AD (n = 60) were recruited. All patients were tested with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to assess their global cognitive profile.
Results:
The MCI-AD and MCI-LB patients did not differ in total MMSE and MoCA scores. However, some sub-items in MMSE and MoCA were shown to be screening markers for differentiating MCI-LB from MCI-AD. In the visuoconstructive test, the total score and hands subitem score in the clock-drawing test were significantly lower in MCI-LB than in MCI-AD. As for the executive function, the ‘animal fluency test’, ‘repeat digits backward test’ and ‘take paper by your right hand’ in MMSE all showed lower scores in MCI-LB compared with MCI-AD. As for memory, ‘velvet’ and ‘church’ in MoCA and ‘ball’ and ‘national flag’ in MMSE had lower scores in MCI-AD than in MCI-LB.
Conclusion:
This study presents the cognitive profile of patients with MCI-LB. In line with the literature on Dementia with Lewy bodies, our results showed lower performance on tests for visuoconstructive and executive function, whereas memory remained relatively spared in the early period. |
| format | Article |
| id | doaj-art-8b88b46ea8ed4b9e95b67895ddb539d9 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-8b88b46ea8ed4b9e95b67895ddb539d92025-02-09T13:56:35ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-08-0164848749210.11622/smedj.2022085Cognitive profile in mild cognitive impairment with Lewy bodiesShuai LiuChunyan LiuXiao-Dan WangHuiru LuYong JiIntroduction: This study aimed to elucidate the cognitive profile of patients with mild cognitive impairment with Lewy bodies (MCI-LB) and to compare it to that of patients with mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Methods: Subjects older than 60 years with probable MCI-LB (n = 60) or MCI-AD (n = 60) were recruited. All patients were tested with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to assess their global cognitive profile. Results: The MCI-AD and MCI-LB patients did not differ in total MMSE and MoCA scores. However, some sub-items in MMSE and MoCA were shown to be screening markers for differentiating MCI-LB from MCI-AD. In the visuoconstructive test, the total score and hands subitem score in the clock-drawing test were significantly lower in MCI-LB than in MCI-AD. As for the executive function, the ‘animal fluency test’, ‘repeat digits backward test’ and ‘take paper by your right hand’ in MMSE all showed lower scores in MCI-LB compared with MCI-AD. As for memory, ‘velvet’ and ‘church’ in MoCA and ‘ball’ and ‘national flag’ in MMSE had lower scores in MCI-AD than in MCI-LB. Conclusion: This study presents the cognitive profile of patients with MCI-LB. In line with the literature on Dementia with Lewy bodies, our results showed lower performance on tests for visuoconstructive and executive function, whereas memory remained relatively spared in the early period.https://journals.lww.com/10.11622/smedj.2022085clock-drawing testlewy bodiesmild cognitive impairmentmini-mental state examinationmontreal cognitive assessment |
| spellingShingle | Shuai Liu Chunyan Liu Xiao-Dan Wang Huiru Lu Yong Ji Cognitive profile in mild cognitive impairment with Lewy bodies Singapore Medical Journal clock-drawing test lewy bodies mild cognitive impairment mini-mental state examination montreal cognitive assessment |
| title | Cognitive profile in mild cognitive impairment with Lewy bodies |
| title_full | Cognitive profile in mild cognitive impairment with Lewy bodies |
| title_fullStr | Cognitive profile in mild cognitive impairment with Lewy bodies |
| title_full_unstemmed | Cognitive profile in mild cognitive impairment with Lewy bodies |
| title_short | Cognitive profile in mild cognitive impairment with Lewy bodies |
| title_sort | cognitive profile in mild cognitive impairment with lewy bodies |
| topic | clock-drawing test lewy bodies mild cognitive impairment mini-mental state examination montreal cognitive assessment |
| url | https://journals.lww.com/10.11622/smedj.2022085 |
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