Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy
Abstract Currently, there are no non‐invasive tools to accurately diagnose deep surgical site bacterial infections before they cause significant anatomical damage in the clinic. An urgent need exists for bacteria‐targeting bifunctional probes for the detection of deep bacterial infections and precis...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202415209 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850149866174414848 |
|---|---|
| author | Youyi Yu Tianming Cui Chang Liu Weitao Yang Bingbo Zhang |
| author_facet | Youyi Yu Tianming Cui Chang Liu Weitao Yang Bingbo Zhang |
| author_sort | Youyi Yu |
| collection | DOAJ |
| description | Abstract Currently, there are no non‐invasive tools to accurately diagnose deep surgical site bacterial infections before they cause significant anatomical damage in the clinic. An urgent need exists for bacteria‐targeting bifunctional probes for the detection of deep bacterial infections and precise in situ treatment. Herein, the bacteria‐targeting 1‐borono‐3,5‐benzenedicarboxylic acid (BBDC) ligand and paramagnetic Gd3 + into one single metal‐organic frameworks (MOFs) are integrated, synergistically realizing bacteria‐specific magnetic resonance imaging (MRI) diagnosis and MRI‐guided antibacterial treatment. Molecular simulations and nitrogen adsorption‐desorption experiments demonstrate that a hierarchical porous structure can be constructed by tuning the Gd3 + /BBDC ratio, which endows the Gd‐BBDC1.25 MOFs with an impressive longitudinal proton relaxivity of 15.81 mM−1 s−1. In particular, the bacteria‐targeting boronic acid group in BBDC remained intact during the MOF synthesis, ensuring that Gd‐BBDC1.25 MOFs have a unique combination of high sensitivity and specificity for bacteria. Through an in situ reduction reaction, silver nanoparticles （Ag NPs）‐modified Gd‐BBDC1.25 MOFs to form Ag@Gd‐BBDC1.25, an interfacial Schottky heterojunction nanozyme, which enhances their peroxidase (POD)‐catalyze activity. Furthermore, it is demonstrated that the bacteria‐targeting Ag@Gd‐BBDC1.25 bifunctional probe can image as few as 105 colony‐forming units (cfu) in vivo and effectively eradicate the bacteria in situ. |
| format | Article |
| id | doaj-art-8b84bb34037f4b92964c152edaf2b950 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-8b84bb34037f4b92964c152edaf2b9502025-08-20T02:26:45ZengWileyAdvanced Science2198-38442025-04-011215n/an/a10.1002/advs.202415209Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial TherapyYouyi Yu0Tianming Cui1Chang Liu2Weitao Yang3Bingbo Zhang4Department of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200065 ChinaShanghai Research Institute for Intelligent Autonomous Systems Tongji University Shanghai 200065 ChinaDepartment of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200065 ChinaDepartment of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200065 ChinaDepartment of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200065 ChinaAbstract Currently, there are no non‐invasive tools to accurately diagnose deep surgical site bacterial infections before they cause significant anatomical damage in the clinic. An urgent need exists for bacteria‐targeting bifunctional probes for the detection of deep bacterial infections and precise in situ treatment. Herein, the bacteria‐targeting 1‐borono‐3,5‐benzenedicarboxylic acid (BBDC) ligand and paramagnetic Gd3 + into one single metal‐organic frameworks (MOFs) are integrated, synergistically realizing bacteria‐specific magnetic resonance imaging (MRI) diagnosis and MRI‐guided antibacterial treatment. Molecular simulations and nitrogen adsorption‐desorption experiments demonstrate that a hierarchical porous structure can be constructed by tuning the Gd3 + /BBDC ratio, which endows the Gd‐BBDC1.25 MOFs with an impressive longitudinal proton relaxivity of 15.81 mM−1 s−1. In particular, the bacteria‐targeting boronic acid group in BBDC remained intact during the MOF synthesis, ensuring that Gd‐BBDC1.25 MOFs have a unique combination of high sensitivity and specificity for bacteria. Through an in situ reduction reaction, silver nanoparticles （Ag NPs）‐modified Gd‐BBDC1.25 MOFs to form Ag@Gd‐BBDC1.25, an interfacial Schottky heterojunction nanozyme, which enhances their peroxidase (POD)‐catalyze activity. Furthermore, it is demonstrated that the bacteria‐targeting Ag@Gd‐BBDC1.25 bifunctional probe can image as few as 105 colony‐forming units (cfu) in vivo and effectively eradicate the bacteria in situ.https://doi.org/10.1002/advs.202415209bacteria targetinghierarchical porous structuremagnetic resonance imagingnanoprobestheranostics |
| spellingShingle | Youyi Yu Tianming Cui Chang Liu Weitao Yang Bingbo Zhang Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy Advanced Science bacteria targeting hierarchical porous structure magnetic resonance imaging nanoprobes theranostics |
| title | Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy |
| title_full | Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy |
| title_fullStr | Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy |
| title_full_unstemmed | Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy |
| title_short | Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy |
| title_sort | tunable hierarchically porous gadolinium based metal organic frameworks for bacteria targeting magnetic resonance imaging and in situ anti bacterial therapy |
| topic | bacteria targeting hierarchical porous structure magnetic resonance imaging nanoprobes theranostics |
| url | https://doi.org/10.1002/advs.202415209 |
| work_keys_str_mv | AT youyiyu tunablehierarchicallyporousgadoliniumbasedmetalorganicframeworksforbacteriatargetingmagneticresonanceimagingandinsituantibacterialtherapy AT tianmingcui tunablehierarchicallyporousgadoliniumbasedmetalorganicframeworksforbacteriatargetingmagneticresonanceimagingandinsituantibacterialtherapy AT changliu tunablehierarchicallyporousgadoliniumbasedmetalorganicframeworksforbacteriatargetingmagneticresonanceimagingandinsituantibacterialtherapy AT weitaoyang tunablehierarchicallyporousgadoliniumbasedmetalorganicframeworksforbacteriatargetingmagneticresonanceimagingandinsituantibacterialtherapy AT bingbozhang tunablehierarchicallyporousgadoliniumbasedmetalorganicframeworksforbacteriatargetingmagneticresonanceimagingandinsituantibacterialtherapy |