Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field
The protective effects of blueberry anthocyanin extracts against damage induced by extremely low-frequency electromagnetic field (ELF-EMF) were investigated in a rat model. Wistar rats were exposed to ELF-EMF with or without the administration of blueberry anthocyanin extracts (50, 100, and 200 mg/k...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453020301324 |
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| author | Xiyun Sun Zihan Xu Yuehua Wang Ning Liu |
| author_facet | Xiyun Sun Zihan Xu Yuehua Wang Ning Liu |
| author_sort | Xiyun Sun |
| collection | DOAJ |
| description | The protective effects of blueberry anthocyanin extracts against damage induced by extremely low-frequency electromagnetic field (ELF-EMF) were investigated in a rat model. Wistar rats were exposed to ELF-EMF with or without the administration of blueberry anthocyanin extracts (50, 100, and 200 mg/kg per day intragastrically once a day) for 30 days. Blueberry anthocyanin extracts supplementation inhibited the decrease in Nissl substance levels, cell membrane integrity, and mitochondrial membrane potential induced by ELF-EMF; prevented the increase in nitric oxide, malondialdehyde, and Ca2+ concentrations; suppressed superoxide dismutase and glutathione depletion; and enhanced the cognitive ability of the rats exposed to ELF-EMF. The protective effects of blueberry anthocyanin extracts against hippocampal neuron injury caused by ELF-EMF were dose-dependent. These results demonstrated that blueberry anthocyanin extracts suppress hippocampal neuron injury caused by ELF-EMF by inhibiting cell membrane damage and oxidative stress pathways, and suggested that blueberry anthocyanin treatment potentially prevents hippocampal neuron injury. |
| format | Article |
| id | doaj-art-8b849c456497450b91d77dde4330b82d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-8b849c456497450b91d77dde4330b82d2025-02-03T05:38:41ZengTsinghua University PressFood Science and Human Wellness2213-45302020-09-0193264271Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic fieldXiyun Sun0Zihan Xu1Yuehua Wang2Ning Liu3College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang City 110866, ChinaCollege of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang City 110866, ChinaCollege of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang City 110866, ChinaCollege of Land and Environment, Shenyang Agricultural University, China; Corresponding author at: College of Land and Environment, Shenyang Agricultural University, 120 Dongling Rd, Shenyang City 110866, China.The protective effects of blueberry anthocyanin extracts against damage induced by extremely low-frequency electromagnetic field (ELF-EMF) were investigated in a rat model. Wistar rats were exposed to ELF-EMF with or without the administration of blueberry anthocyanin extracts (50, 100, and 200 mg/kg per day intragastrically once a day) for 30 days. Blueberry anthocyanin extracts supplementation inhibited the decrease in Nissl substance levels, cell membrane integrity, and mitochondrial membrane potential induced by ELF-EMF; prevented the increase in nitric oxide, malondialdehyde, and Ca2+ concentrations; suppressed superoxide dismutase and glutathione depletion; and enhanced the cognitive ability of the rats exposed to ELF-EMF. The protective effects of blueberry anthocyanin extracts against hippocampal neuron injury caused by ELF-EMF were dose-dependent. These results demonstrated that blueberry anthocyanin extracts suppress hippocampal neuron injury caused by ELF-EMF by inhibiting cell membrane damage and oxidative stress pathways, and suggested that blueberry anthocyanin treatment potentially prevents hippocampal neuron injury.http://www.sciencedirect.com/science/article/pii/S2213453020301324Blueberry anthocyanin extractsProtective effectsExtremely low-frequency electromagnetic fieldHippocampal neuron |
| spellingShingle | Xiyun Sun Zihan Xu Yuehua Wang Ning Liu Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field Food Science and Human Wellness Blueberry anthocyanin extracts Protective effects Extremely low-frequency electromagnetic field Hippocampal neuron |
| title | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field |
| title_full | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field |
| title_fullStr | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field |
| title_full_unstemmed | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field |
| title_short | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field |
| title_sort | protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low frequency electromagnetic field |
| topic | Blueberry anthocyanin extracts Protective effects Extremely low-frequency electromagnetic field Hippocampal neuron |
| url | http://www.sciencedirect.com/science/article/pii/S2213453020301324 |
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