Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation
Introduction. Previous studies have shown that a higher serum interleukin- (IL-) 6 level is associated with a higher risk of acute kidney injury (AKI) development after major nontransplant surgery. Our study investigated the potential association of preoperative serum cytokine profiles with new AKI...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/8256193 |
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| author | Min Suk Chae Youngchan Kim Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong |
| author_facet | Min Suk Chae Youngchan Kim Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong |
| author_sort | Min Suk Chae |
| collection | DOAJ |
| description | Introduction. Previous studies have shown that a higher serum interleukin- (IL-) 6 level is associated with a higher risk of acute kidney injury (AKI) development after major nontransplant surgery. Our study investigated the potential association of preoperative serum cytokine profiles with new AKI development in patients who underwent living donor liver transplantation (LDLT). Methods. Serum levels of cytokines IL-2, IL-6, IL-10, IL-12, and IL-17, interferon-γ, and tumor necrosis factor- (TNF-) α were measured in 226 LDLT recipients preoperatively and analyzed retrospectively. Recipients with a preoperative functional impairment of the kidney were excluded. AKI was defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results. In a univariate regression model, IL-6, IL-17, and TNF-α levels showed an association with AKI development after LDLT. Multivariate analysis showed an independent association of the preoperative serum IL-6 level with AKI development after LDLT and a significant relationship between higher serum IL-6 levels and a greater likelihood of developing AKI. Serum IL-6 levels were higher in patients with stage 3 AKI than in patients who did not develop AKI. Conclusions. Our results support the need for further investigations of IL-6 as a predictor of AKI development in patients undergoing LDLT. |
| format | Article |
| id | doaj-art-8b800f2f846d4fbd8f845f3ce8366355 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8b800f2f846d4fbd8f845f3ce83663552025-08-20T02:09:13ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/82561938256193Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver TransplantationMin Suk Chae0Youngchan Kim1Hyun Sik Chung2Chul Soo Park3Jaemin Lee4Jong Ho Choi5Sang Hyun Hong6Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaIntroduction. Previous studies have shown that a higher serum interleukin- (IL-) 6 level is associated with a higher risk of acute kidney injury (AKI) development after major nontransplant surgery. Our study investigated the potential association of preoperative serum cytokine profiles with new AKI development in patients who underwent living donor liver transplantation (LDLT). Methods. Serum levels of cytokines IL-2, IL-6, IL-10, IL-12, and IL-17, interferon-γ, and tumor necrosis factor- (TNF-) α were measured in 226 LDLT recipients preoperatively and analyzed retrospectively. Recipients with a preoperative functional impairment of the kidney were excluded. AKI was defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results. In a univariate regression model, IL-6, IL-17, and TNF-α levels showed an association with AKI development after LDLT. Multivariate analysis showed an independent association of the preoperative serum IL-6 level with AKI development after LDLT and a significant relationship between higher serum IL-6 levels and a greater likelihood of developing AKI. Serum IL-6 levels were higher in patients with stage 3 AKI than in patients who did not develop AKI. Conclusions. Our results support the need for further investigations of IL-6 as a predictor of AKI development in patients undergoing LDLT.http://dx.doi.org/10.1155/2018/8256193 |
| spellingShingle | Min Suk Chae Youngchan Kim Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation Mediators of Inflammation |
| title | Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation |
| title_full | Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation |
| title_fullStr | Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation |
| title_full_unstemmed | Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation |
| title_short | Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation |
| title_sort | predictive role of serum cytokine profiles in acute kidney injury after living donor liver transplantation |
| url | http://dx.doi.org/10.1155/2018/8256193 |
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