The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study
<b>Background:</b> Vitamin D deficiency is thought to increase the likelihood of insulin resistance (IR) and diabetes onset. The objective of this study was to examine the association between the triglyceride glucose (TyG) index and vitamin D levels in individuals with prediabetes and ty...
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2024-10-01
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| author | Roshan Kumar Mahat Prasanna Kumar Rathor Vedika Rathore Manisha Arora Suchismita Panda Gujaram Marndi |
| author_facet | Roshan Kumar Mahat Prasanna Kumar Rathor Vedika Rathore Manisha Arora Suchismita Panda Gujaram Marndi |
| author_sort | Roshan Kumar Mahat |
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| description | <b>Background:</b> Vitamin D deficiency is thought to increase the likelihood of insulin resistance (IR) and diabetes onset. The objective of this study was to examine the association between the triglyceride glucose (TyG) index and vitamin D levels in individuals with prediabetes and type 2 diabetes mellitus (T2DM) in the tribal community of India. <b>Methods:</b> This study included 270 participants, consisting of 90 individuals with prediabetes, 90 individuals with T2DM, and 90 control patients. Anthropometric and biochemical characteristics were evaluated in all participants. 25-hydroxyvitamin D [25(OH)D] levels were measured using a chemiluminescent immunoassay. The TyG index was computed as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Spearman correlation analysis and linear regression analysis were performed to assess the relationship between the TyG index and 25(OH)D levels in people diagnosed with prediabetes and T2DM. The optimum cut-off value of the TyG index for detecting vitamin D deficiency was determined by receiver operating characteristic (ROC) curve analysis. <b>Results:</b> We observed a significant reduction in vitamin D levels in individuals with prediabetes and T2DM compared to those in the control group. However, the TyG index was significantly greater in individuals with prediabetes and T2DM than in controls. Statistical analysis revealed a significant negative correlation between the TyG index and 25(OH)D in both prediabetes and T2DM. <b>Conclusions:</b> The TyG index demonstrated a negative association with vitamin D levels and was identified as an independent predictor of vitamin D deficiency in individuals with prediabetes and T2DM. |
| format | Article |
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| institution | Kabale University |
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| publishDate | 2024-10-01 |
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| spelling | doaj-art-8b7fd0659e854fbcb0f8f08e030430912024-12-27T14:12:22ZengMDPI AGBioMed2673-84302024-10-014440441810.3390/biomed4040032The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional StudyRoshan Kumar Mahat0Prasanna Kumar Rathor1Vedika Rathore2Manisha Arora3Suchismita Panda4Gujaram Marndi5Department of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar 758002, IndiaDepartment of Medicine, Pandit Raghunath Murmu Medical College and Hospital, Baripada 757107, IndiaDepartment of Biochemistry, Shyam Shah Medical College, Rewa 486001, IndiaDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA 31901, USADepartment of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar 758002, IndiaDepartment of Pharmacology, Dharanidhar Medical College and Hospital, Keonjhar 758002, India<b>Background:</b> Vitamin D deficiency is thought to increase the likelihood of insulin resistance (IR) and diabetes onset. The objective of this study was to examine the association between the triglyceride glucose (TyG) index and vitamin D levels in individuals with prediabetes and type 2 diabetes mellitus (T2DM) in the tribal community of India. <b>Methods:</b> This study included 270 participants, consisting of 90 individuals with prediabetes, 90 individuals with T2DM, and 90 control patients. Anthropometric and biochemical characteristics were evaluated in all participants. 25-hydroxyvitamin D [25(OH)D] levels were measured using a chemiluminescent immunoassay. The TyG index was computed as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Spearman correlation analysis and linear regression analysis were performed to assess the relationship between the TyG index and 25(OH)D levels in people diagnosed with prediabetes and T2DM. The optimum cut-off value of the TyG index for detecting vitamin D deficiency was determined by receiver operating characteristic (ROC) curve analysis. <b>Results:</b> We observed a significant reduction in vitamin D levels in individuals with prediabetes and T2DM compared to those in the control group. However, the TyG index was significantly greater in individuals with prediabetes and T2DM than in controls. Statistical analysis revealed a significant negative correlation between the TyG index and 25(OH)D in both prediabetes and T2DM. <b>Conclusions:</b> The TyG index demonstrated a negative association with vitamin D levels and was identified as an independent predictor of vitamin D deficiency in individuals with prediabetes and T2DM.https://www.mdpi.com/2673-8430/4/4/32prediabetestype 2 diabetes mellitusvitamin Dtriglyceride glucose index |
| spellingShingle | Roshan Kumar Mahat Prasanna Kumar Rathor Vedika Rathore Manisha Arora Suchismita Panda Gujaram Marndi The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study BioMed prediabetes type 2 diabetes mellitus vitamin D triglyceride glucose index |
| title | The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study |
| title_full | The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study |
| title_fullStr | The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study |
| title_full_unstemmed | The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study |
| title_short | The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study |
| title_sort | relationship between vitamin d and tyg index in prediabetes and type 2 diabetes mellitus among an indian tribal community a cross sectional study |
| topic | prediabetes type 2 diabetes mellitus vitamin D triglyceride glucose index |
| url | https://www.mdpi.com/2673-8430/4/4/32 |
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