Altered dendritic morphology of MEC II pyramidal and stellate cells in Rett syndrome mice

Altered dendritic morphology of MEC II pyramidal and stellate cells in Rett syndrome mice

IntroductionMutations in the methyl-CpG-binding protein-2 gene (MECP2), which cause Rett syndrome (RTT), disrupt neuronal activity; however, the impact of the MECP2 loss-of-function on the cytoarchitecture of medial entorhinal cortex layer II (MECII) neurons—crucial for spatial memory and learning—r...

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Bibliographic Details
Main Authors: Manigandan Krishnan, Ayishal B. Mydeen, Mohammed M. Nakhal, Marwa F. Ibrahim, Richard L. Jayaraj, Milos R. Ljubisavljevic, Mohammad I. K. Hamad, Fatima Y. Ismail
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neuroanatomy
Subjects:
Rett syndrome
Mecp2 mouse model
dendritic branching
pyramidal cells
stellate cells
medial entorhinal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2025.1580435/full
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