Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies
The classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. Based on recent epidemiological studies, NK-cell lymphomas occur almo...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/624040 |
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| author | Tiffany Tang Kevin Tay Richard Quek Miriam Tao Soo Yong Tan Leonard Tan Soon Thye Lim |
| author_facet | Tiffany Tang Kevin Tay Richard Quek Miriam Tao Soo Yong Tan Leonard Tan Soon Thye Lim |
| author_sort | Tiffany Tang |
| collection | DOAJ |
| description | The classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. Based on recent epidemiological studies, NK-cell lymphomas occur almost exclusively in Asia and South America, although T-cell lymphomas appear to occur in the East as commonly as in the West. Due to the low prevalence of this disease, diagnosis and optimal treatment of patients have not been studied prospectively in large randomized trials. Nevertheless, there has been development in the understanding of T-cell lymphomas and how they should be managed; FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. More work, however, needs to be done, and international collaboration will be pertinent to deriving meaningful results from future clinical studies. |
| format | Article |
| id | doaj-art-8b7b1755fbc04296aed3c0908c69fb69 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-8b7b1755fbc04296aed3c0908c69fb692025-02-03T05:52:46ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/624040624040Peripheral T-Cell Lymphoma: Review and Updates of Current Management StrategiesTiffany Tang0Kevin Tay1Richard Quek2Miriam Tao3Soo Yong Tan4Leonard Tan5Soon Thye Lim6Department of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeDepartment of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeDepartment of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeDepartment of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeDepartment of Pathology, Singapore General Hospital, Outram Road, 169608, SingaporeDepartment of Pathology, Singapore General Hospital, Outram Road, 169608, SingaporeDepartment of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeThe classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. Based on recent epidemiological studies, NK-cell lymphomas occur almost exclusively in Asia and South America, although T-cell lymphomas appear to occur in the East as commonly as in the West. Due to the low prevalence of this disease, diagnosis and optimal treatment of patients have not been studied prospectively in large randomized trials. Nevertheless, there has been development in the understanding of T-cell lymphomas and how they should be managed; FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. More work, however, needs to be done, and international collaboration will be pertinent to deriving meaningful results from future clinical studies.http://dx.doi.org/10.1155/2010/624040 |
| spellingShingle | Tiffany Tang Kevin Tay Richard Quek Miriam Tao Soo Yong Tan Leonard Tan Soon Thye Lim Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies Advances in Hematology |
| title | Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies |
| title_full | Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies |
| title_fullStr | Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies |
| title_full_unstemmed | Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies |
| title_short | Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies |
| title_sort | peripheral t cell lymphoma review and updates of current management strategies |
| url | http://dx.doi.org/10.1155/2010/624040 |
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