Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats
ABSTRACT Objective: To examine the relationship between hormonal changes, particularly estrogen, and lacrimal gland function in dry eye syndrome using a surgically induced menopausal rat model. Methods: Twenty-four female rats were divided into four groups: control, ovariectomized, ovariectomized...
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Sociedade Brasileira de Oftalmologia
2025-03-01
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| Series: | Revista Brasileira de Oftalmologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100209&tlng=en |
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| author | Vinícius da Silva Varandas Caio Brenno Abreu Márcio Penha Morterá Rodrigues Christina Maeda Taliya Artur Marin Varandas Adroaldo de Alencar Costa Filho |
| author_facet | Vinícius da Silva Varandas Caio Brenno Abreu Márcio Penha Morterá Rodrigues Christina Maeda Taliya Artur Marin Varandas Adroaldo de Alencar Costa Filho |
| author_sort | Vinícius da Silva Varandas |
| collection | DOAJ |
| description | ABSTRACT Objective: To examine the relationship between hormonal changes, particularly estrogen, and lacrimal gland function in dry eye syndrome using a surgically induced menopausal rat model. Methods: Twenty-four female rats were divided into four groups: control, ovariectomized, ovariectomized with estrogen replacement, and ovariectomized with phytoestrogen replacement. Rats with regular estrous cycles were selected via vaginal cytology. Ovariectomy was performed on ovariectomized groups, and ovariectomized with estrogen replacement and ovariectomized with phytoestrogen replacement groups received hormonal interventions. Histological analysis assessed collagen content, cellular volume, and apoptosis in lacrimal gland tissues. Results: Collagen content significantly decreased in the ovariectomized group compared to control, emphasizing the importance of tissue integrity. Cellular volume increased in ovariectomized with estrogen replacement and ovariectomized with phytoestrogen replacement groups, indicating hormonal influence. Apoptosis levels varied, with higher levels in ovariectomized and ovariectomized with estrogen replacement groups, while ovariectomized with phytoestrogen replacement resembled Control Group. Conclusion: Estrogen likely modulates lacrimal gland function and tear film stability. Collagen content underscores tissue's integrity role in gland function. |
| format | Article |
| id | doaj-art-8b7952b66d934eaa9a467708a065076b |
| institution | OA Journals |
| issn | 1982-8551 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira de Oftalmologia |
| record_format | Article |
| series | Revista Brasileira de Oftalmologia |
| spelling | doaj-art-8b7952b66d934eaa9a467708a065076b2025-08-20T01:50:33ZengSociedade Brasileira de OftalmologiaRevista Brasileira de Oftalmologia1982-85512025-03-018410.37039/1982.8551.2025.0016Impact of estrogen on morphology and programmed cell death in the meibomian glands of ratsVinícius da Silva Varandashttps://orcid.org/0009-0002-3951-6330Caio Brenno Abreuhttps://orcid.org/0000-0002-5607-6237Márcio Penha Morterá Rodrigueshttps://orcid.org/0000-0003-2771-1542Christina Maeda Taliyahttps://orcid.org/0000-0002-8019-628XArtur Marin Varandashttps://orcid.org/0009-0005-1566-4517Adroaldo de Alencar Costa Filhohttps://orcid.org/0009-0007-9297-9111ABSTRACT Objective: To examine the relationship between hormonal changes, particularly estrogen, and lacrimal gland function in dry eye syndrome using a surgically induced menopausal rat model. Methods: Twenty-four female rats were divided into four groups: control, ovariectomized, ovariectomized with estrogen replacement, and ovariectomized with phytoestrogen replacement. Rats with regular estrous cycles were selected via vaginal cytology. Ovariectomy was performed on ovariectomized groups, and ovariectomized with estrogen replacement and ovariectomized with phytoestrogen replacement groups received hormonal interventions. Histological analysis assessed collagen content, cellular volume, and apoptosis in lacrimal gland tissues. Results: Collagen content significantly decreased in the ovariectomized group compared to control, emphasizing the importance of tissue integrity. Cellular volume increased in ovariectomized with estrogen replacement and ovariectomized with phytoestrogen replacement groups, indicating hormonal influence. Apoptosis levels varied, with higher levels in ovariectomized and ovariectomized with estrogen replacement groups, while ovariectomized with phytoestrogen replacement resembled Control Group. Conclusion: Estrogen likely modulates lacrimal gland function and tear film stability. Collagen content underscores tissue's integrity role in gland function.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100209&tlng=enMeibomian gland dysfunctionDry eye syndromesLacrimal apparatusEstrogens |
| spellingShingle | Vinícius da Silva Varandas Caio Brenno Abreu Márcio Penha Morterá Rodrigues Christina Maeda Taliya Artur Marin Varandas Adroaldo de Alencar Costa Filho Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats Revista Brasileira de Oftalmologia Meibomian gland dysfunction Dry eye syndromes Lacrimal apparatus Estrogens |
| title | Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| title_full | Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| title_fullStr | Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| title_full_unstemmed | Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| title_short | Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| title_sort | impact of estrogen on morphology and programmed cell death in the meibomian glands of rats |
| topic | Meibomian gland dysfunction Dry eye syndromes Lacrimal apparatus Estrogens |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100209&tlng=en |
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