Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort
Background: Clinical patterns and disease activity burden of psoriatic arthritis (PsA) varies in different parts of the world. There are limited studies from the Indian subcontinent. Aims: To study the cutaneous and articular profile of PsA and describe their disease activity with validated outcome...
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SAGE Publishing
2022-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=4;spage=340;epage=346;aulast=Kodishala |
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| author | Chanakya Kodishala Vineeta Shobha S Chandrashekara Sharath Kumar Vikram Haridas Vijay K R Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanand Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikram Raj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivasa Ramya Janardana Benzeeta Pinto Beenish Nazir A S Harshini K M Mahendranath |
| author_facet | Chanakya Kodishala Vineeta Shobha S Chandrashekara Sharath Kumar Vikram Haridas Vijay K R Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanand Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikram Raj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivasa Ramya Janardana Benzeeta Pinto Beenish Nazir A S Harshini K M Mahendranath |
| author_sort | Chanakya Kodishala |
| collection | DOAJ |
| description | Background: Clinical patterns and disease activity burden of psoriatic arthritis (PsA) varies in different parts of the world. There are limited studies from the Indian subcontinent.
Aims: To study the cutaneous and articular profile of PsA and describe their disease activity with validated outcome measures.
Methods: Karnataka psoriatic arthritis cohort study is a multicenter, prospective, cross-sectional, observational study which included all consecutive PsA patients defined by Classification criteria for psoriatic arthritis (CASPAR) from 18 rheumatology centers.
Results: A total of 549 PsA patients (M: F: 6:5), mean age 38.4 (±14) years were included. PsA preceded psoriasis in 81 (14.7%) while simultaneous onset was noted in 117 (21.5%). Plaque lesions (330 [78.8%]) and scalp (210 [49.2%]) were the most common type and site. Mild, moderate, and severe skin disease was noted in 480 (80%), 50 (9.3%), and 57 (10.6%) patients, respectively. Mean disease activity in PsA (DAPSA) was 18.8 (16.6); 100 (19.9%) were in remission. Low, moderate, and high joint disease activity was found in 145 (28.8%), 137 (27.2%), and 123 (24.5%), respectively. There was no correlation between skin and joint disease. Polyarthritis (216 [40.7%]) and oligoarthritis (202 [38.1%]) were the most frequent PsA subtypes. Those with a higher DAPSA (>28) were older (P = 0.02), had a shorter duration of psoriasis (P = 0.02) and higher psoriatic area and severity index scores (P = 0.0001).
Conclusions: We report high articular disease activity in half while cutaneous disease activity was minimal in majority. |
| format | Article |
| id | doaj-art-8b72347ee09f483a89f34b06bc9fa856 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-8b72347ee09f483a89f34b06bc9fa8562025-02-03T10:54:59ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012022-01-0117434034610.4103/injr.injr_213_21Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis CohortChanakya KodishalaVineeta ShobhaS ChandrashekaraSharath KumarVikram HaridasVijay K R RaoRamesh JoisManisha DawareYogesh Preet SinghShweta SinghaiB G DharmanandPramod ChebbiR SubramanianAshwini KamathUma KarjiigiVikram Raj K JainChethana DharmapalaiahShiva PrasadC SrinivasaRamya JanardanaBenzeeta PintoBeenish NazirA S HarshiniK M MahendranathBackground: Clinical patterns and disease activity burden of psoriatic arthritis (PsA) varies in different parts of the world. There are limited studies from the Indian subcontinent. Aims: To study the cutaneous and articular profile of PsA and describe their disease activity with validated outcome measures. Methods: Karnataka psoriatic arthritis cohort study is a multicenter, prospective, cross-sectional, observational study which included all consecutive PsA patients defined by Classification criteria for psoriatic arthritis (CASPAR) from 18 rheumatology centers. Results: A total of 549 PsA patients (M: F: 6:5), mean age 38.4 (±14) years were included. PsA preceded psoriasis in 81 (14.7%) while simultaneous onset was noted in 117 (21.5%). Plaque lesions (330 [78.8%]) and scalp (210 [49.2%]) were the most common type and site. Mild, moderate, and severe skin disease was noted in 480 (80%), 50 (9.3%), and 57 (10.6%) patients, respectively. Mean disease activity in PsA (DAPSA) was 18.8 (16.6); 100 (19.9%) were in remission. Low, moderate, and high joint disease activity was found in 145 (28.8%), 137 (27.2%), and 123 (24.5%), respectively. There was no correlation between skin and joint disease. Polyarthritis (216 [40.7%]) and oligoarthritis (202 [38.1%]) were the most frequent PsA subtypes. Those with a higher DAPSA (>28) were older (P = 0.02), had a shorter duration of psoriasis (P = 0.02) and higher psoriatic area and severity index scores (P = 0.0001). Conclusions: We report high articular disease activity in half while cutaneous disease activity was minimal in majority.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=4;spage=340;epage=346;aulast=Kodishalaarthritispsoriasispsoriatic |
| spellingShingle | Chanakya Kodishala Vineeta Shobha S Chandrashekara Sharath Kumar Vikram Haridas Vijay K R Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanand Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikram Raj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivasa Ramya Janardana Benzeeta Pinto Beenish Nazir A S Harshini K M Mahendranath Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort Indian Journal of Rheumatology arthritis psoriasis psoriatic |
| title | Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort |
| title_full | Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort |
| title_fullStr | Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort |
| title_full_unstemmed | Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort |
| title_short | Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort |
| title_sort | clinical profiling of psoriatic arthritis an observational cross sectional study from karnataka psoriatic arthritis cohort |
| topic | arthritis psoriasis psoriatic |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=4;spage=340;epage=346;aulast=Kodishala |
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