Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs
Abstract Ischemic ulcers due to compromised microcirculation of the lower limbs cause painful ulcers that represent a challenge for the correct diagnosis and treatment. Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ischemic ulcer are part of this group and present some similarit...
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Sociedade Brasileira de Dermatologia
2025-04-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200200&lng=en&tlng=en |
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| _version_ | 1849721815411195904 |
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| author | Priscila Neri Lacerda Lucas Campos Garcia Izabelle Ferreira da Silva Mazeto Hélio Amante Miot Luciana Patricia Fernandes Abbade |
| author_facet | Priscila Neri Lacerda Lucas Campos Garcia Izabelle Ferreira da Silva Mazeto Hélio Amante Miot Luciana Patricia Fernandes Abbade |
| author_sort | Priscila Neri Lacerda |
| collection | DOAJ |
| description | Abstract Ischemic ulcers due to compromised microcirculation of the lower limbs cause painful ulcers that represent a challenge for the correct diagnosis and treatment. Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ischemic ulcer are part of this group and present some similarities due to microvascular occlusive impairment. They are often misdiagnosed as inflammatory ulcers such as pyoderma gangrenosum and vasculitis. This review discusses the pathophysiology, risk factors, clinical aspects, differential diagnoses, histopathology, and presents a therapeutic update of livedoid vasculopathy, calciphylaxis, and Martorell’s ulcer. Although they are less frequent causes of chronic ulcers, a correct diagnosis is essential to reduce the chance of erroneous therapies that may impact morbidity and mortality related to these conditions. |
| format | Article |
| id | doaj-art-8b71f11e182240a9a1fa8daa876a4abc |
| institution | DOAJ |
| issn | 0365-0596 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj-art-8b71f11e182240a9a1fa8daa876a4abc2025-08-20T03:11:32ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962025-04-01100210.1016/j.abd.2024.09.004Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbsPriscila Neri Lacerdahttps://orcid.org/0000-0001-8100-5978Lucas Campos Garciahttps://orcid.org/0000-0002-7883-5986Izabelle Ferreira da Silva Mazetohttps://orcid.org/0000-0003-2325-8701Hélio Amante Miothttps://orcid.org/0000-0002-2596-9294Luciana Patricia Fernandes Abbadehttps://orcid.org/0000-0002-0334-2079Abstract Ischemic ulcers due to compromised microcirculation of the lower limbs cause painful ulcers that represent a challenge for the correct diagnosis and treatment. Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ischemic ulcer are part of this group and present some similarities due to microvascular occlusive impairment. They are often misdiagnosed as inflammatory ulcers such as pyoderma gangrenosum and vasculitis. This review discusses the pathophysiology, risk factors, clinical aspects, differential diagnoses, histopathology, and presents a therapeutic update of livedoid vasculopathy, calciphylaxis, and Martorell’s ulcer. Although they are less frequent causes of chronic ulcers, a correct diagnosis is essential to reduce the chance of erroneous therapies that may impact morbidity and mortality related to these conditions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200200&lng=en&tlng=enCalcific uremic arteriolopathyCalciphylaxisHypertensionLivedoid vasculopathy |
| spellingShingle | Priscila Neri Lacerda Lucas Campos Garcia Izabelle Ferreira da Silva Mazeto Hélio Amante Miot Luciana Patricia Fernandes Abbade Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs Anais Brasileiros de Dermatologia Calcific uremic arteriolopathy Calciphylaxis Hypertension Livedoid vasculopathy |
| title | Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| title_full | Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| title_fullStr | Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| title_full_unstemmed | Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| title_short | Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| title_sort | livedoid vasculopathy calciphylaxis and martorell s hypertensive ulcer update on ischemic ulcers due to impaired microcirculation of the lower limbs |
| topic | Calcific uremic arteriolopathy Calciphylaxis Hypertension Livedoid vasculopathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200200&lng=en&tlng=en |
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