A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin
Abstract A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH2 monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surfa...
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| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83614-x |
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| author | R. Foulady-Dehaghi Sh. Sohrabnezhad M. Hadavi |
| author_facet | R. Foulady-Dehaghi Sh. Sohrabnezhad M. Hadavi |
| author_sort | R. Foulady-Dehaghi |
| collection | DOAJ |
| description | Abstract A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH2 monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surface area and pore volume compared to the base COF, certified by powder X-ray diffraction spectroscopy and Brunauer–Emmett–Teller technique. Kinetically controlled and sustained curcumin release profiles were investigated using the as-prepared curcumin-loaded drug delivery systems (C@DDSs) in neutral and acidic pH media. C-loaded hybrid nanostructure prepared via the solvent-free drug loading process displayed a high entrapment efficiency (35.96%) and improved release in the acidic environment specific to cancer cells (pH = 4.5: 36.8%, pH = 7.4: 15.27%). In conclusion, we illustrated the utility of C@DDS as an in vitro drug delivery system in MDA-MB-231 cells. C@DDSs represented the time-dependent release of curcumin followed by cell death. Therefore, the reported PI-COF/MCM-NH2 system can be considered a new biocompatible carrier in COF research as a sensitive drug delivery system. |
| format | Article |
| id | doaj-art-8b6f44fb764e4c029ea9e8a7ead5b49b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8b6f44fb764e4c029ea9e8a7ead5b49b2025-01-05T12:30:32ZengNature PortfolioScientific Reports2045-23222024-12-0114111510.1038/s41598-024-83614-xA new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcuminR. Foulady-Dehaghi0Sh. Sohrabnezhad1M. Hadavi2Faculty of Chemistry, University of GuilanFaculty of Chemistry, University of GuilanDepartment of Biology, Faculty of Science, University of GuilanAbstract A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH2 monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surface area and pore volume compared to the base COF, certified by powder X-ray diffraction spectroscopy and Brunauer–Emmett–Teller technique. Kinetically controlled and sustained curcumin release profiles were investigated using the as-prepared curcumin-loaded drug delivery systems (C@DDSs) in neutral and acidic pH media. C-loaded hybrid nanostructure prepared via the solvent-free drug loading process displayed a high entrapment efficiency (35.96%) and improved release in the acidic environment specific to cancer cells (pH = 4.5: 36.8%, pH = 7.4: 15.27%). In conclusion, we illustrated the utility of C@DDS as an in vitro drug delivery system in MDA-MB-231 cells. C@DDSs represented the time-dependent release of curcumin followed by cell death. Therefore, the reported PI-COF/MCM-NH2 system can be considered a new biocompatible carrier in COF research as a sensitive drug delivery system.https://doi.org/10.1038/s41598-024-83614-xDrug deliveryCovalent organic frameworkCurcuminpH-sensitiveAnticancer |
| spellingShingle | R. Foulady-Dehaghi Sh. Sohrabnezhad M. Hadavi A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin Scientific Reports Drug delivery Covalent organic framework Curcumin pH-sensitive Anticancer |
| title | A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin |
| title_full | A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin |
| title_fullStr | A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin |
| title_full_unstemmed | A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin |
| title_short | A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin |
| title_sort | new biocompatible cof mcm nanoporous hybrid dds for ph controlled delivery of curcumin |
| topic | Drug delivery Covalent organic framework Curcumin pH-sensitive Anticancer |
| url | https://doi.org/10.1038/s41598-024-83614-x |
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